Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

Derin B. Keskin; Annabelle Anandappa; Jing Sun; Itay Tirosh; Nathan D. Mathewson; Shuqiang Li; Giacomo Oliveira; Anita Giobbie‐Hurder; Kristen D. Felt; Evisa Gjini; Sachet A. Shukla; Zhuting Hu; Letitia Li; Phuong M. Le; Rosa Lundbye Allesøe; Alyssa Richman; Monika S. Kowalczyk; Sara Abdelrahman; Jack Geduldig; Sarah Charbonneau; Kristine Pelton; J. Bryan Iorgulescu; Liudmila Elagina; Wandi Zhang; Oriol Olive; Christine McCluskey; Lars Rønn Olsen; Jonathan Stevens; William J. Lane; Andres Μ. Salazar; Heather Daley; Patrick Y. Wen; E. Antonio Chiocca; Maegan Harden; Niall J. Lennon; Stacey Gabriel; Gad Getz; Eric S. Lander; Aviv Regev; Jerome Ritz; Donna Neuberg; Scott J. Rodig; Keith L. Ligon; Mario L. Suvà; Kai W. Wucherpfennig; Nir Hacohen; Edward F. Fritsch; Kenneth J. Livak; Patrick A. Ott; Catherine J. Wu; David A. Reardon

doi:10.1038/s41586-018-0792-9

Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

Derin B. Keskin(Broad Institute), Annabelle Anandappa(Harvard University), Jing Sun(Dana-Farber Cancer Institute), Itay Tirosh(Broad Institute), Nathan D. Mathewson(Harvard University), Shuqiang Li(Broad Institute), Giacomo Oliveira(Dana-Farber Cancer Institute), Anita Giobbie‐Hurder(Dana-Farber Cancer Institute), Kristen D. Felt(Dana-Farber Cancer Institute), Evisa Gjini(Dana-Farber Cancer Institute), Sachet A. Shukla(Dana-Farber Cancer Institute), Zhuting Hu(Dana-Farber Cancer Institute), Letitia Li(Dana-Farber Cancer Institute), Phuong M. Le(Dana-Farber Cancer Institute), Rosa Lundbye Allesøe(Dana-Farber Cancer Institute), Alyssa Richman(Broad Institute), Monika S. Kowalczyk(Broad Institute), Sara Abdelrahman(Dana-Farber Cancer Institute), Jack Geduldig(Dana-Farber Cancer Institute), Sarah Charbonneau(Dana-Farber Cancer Institute), Kristine Pelton(Dana-Farber Cancer Institute), J. Bryan Iorgulescu(Brigham and Women's Hospital), Liudmila Elagina(Broad Institute), Wandi Zhang(Dana-Farber Cancer Institute), Oriol Olive(Dana-Farber Cancer Institute), Christine McCluskey(Dana-Farber Cancer Institute), Lars Rønn Olsen(Technical University of Denmark), Jonathan Stevens(Brigham and Women's Hospital), William J. Lane(Brigham and Women's Hospital), Andres Μ. Salazar(Oncovir (United States)), Heather Daley(Dana-Farber Cancer Institute), Patrick Y. Wen(Brigham and Women's Hospital), E. Antonio Chiocca(Brigham and Women's Hospital), Maegan Harden(Broad Institute), Niall J. Lennon(Broad Institute), Stacey Gabriel(Broad Institute), Gad Getz(Broad Institute), Eric S. Lander(Broad Institute), Aviv Regev(Broad Institute), Jerome Ritz(Brigham and Women's Hospital), Donna Neuberg(Dana-Farber Cancer Institute), Scott J. Rodig(Brigham and Women's Hospital), Keith L. Ligon(Broad Institute), Mario L. Suvà(Broad Institute), Kai W. Wucherpfennig(Harvard University), Nir Hacohen(Broad Institute), Edward F. Fritsch(Broad Institute), Kenneth J. Livak(Dana-Farber Cancer Institute), Patrick A. Ott(Brigham and Women's Hospital), Catherine J. Wu(Broad Institute), David A. Reardon(Brigham and Women's Hospital)

Nature

December 19, 2018

10.1038/s41586-018-0792-9

Cited by 1,420Open Access

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