Exogenous sphingomyelinase mediates MSC-derived EV biogenesis and enhances potency via repackaging of molecular cargo

Daniel Shah(Georgia Institute of Technology), Edward A. Botchwey(Georgia Institute of Technology), Todd Sulchek(Georgia Institute of Technology), Afra I. Toma(The Wallace H. Coulter Department of Biomedical Engineering), Hongmanlin Zhang(Georgia Institute of Technology), S’Dravious A. DeVeaux(Georgia Institute of Technology), Young C. Jang(Georgia Institute of Technology), Tosin A. Adedipe(Georgia Institute of Technology), Krishna A. Patel(Children's Healthcare of Atlanta), Steven L. Goudy(The Wallace H. Coulter Department of Biomedical Engineering), Krishnendu Roy(The University of Texas at Austin), Nathan F. Chiappa(Georgia Institute of Technology), Alan Y. Liu(Georgia Institute of Technology)
iScience
February 11, 2026
Cited by 5


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