TIGIT disruption rescues the antitumor activity of low avidity TCR-engineered T cells by increasing TCR signal strength

Martina Spiga(Vita-Salute San Raffaele University), Hana Algül(TUM Klinikum), Laura Perani(Vita-Salute San Raffaele University), Zulma Magnani(Vita-Salute San Raffaele University), Anna Mondino(Vita-Salute San Raffaele University), Eliana Ruggiero(Vita-Salute San Raffaele University), Samuele Ferrari(Vita-Salute San Raffaele University), Maria Pia Protti(Vita-Salute San Raffaele University), Chiara Balestrieri(Vita-Salute San Raffaele University), Neda Mohammadi(Vita-Salute San Raffaele University), Stefano Crippa(Vita-Salute San Raffaele University), Arianna Pocaterra(University of Padua), Claudio Doglioni(Vita-Salute San Raffaele University), Giulia Di Lullo(Vita-Salute San Raffaele University), Massimo Falconi(Vita-Salute San Raffaele University), Giovanni Sitia(Vita-Salute San Raffaele University), Renato Ostuni(Vita-Salute San Raffaele University), Danilo Abbati(Vita-Salute San Raffaele University), Alessia Potenza(Vita-Salute San Raffaele University), Oronza A. Botrugno(European Institute of Oncology), Maximilian Reichert(TUM Klinikum), Laura Conte(Vita-Salute San Raffaele University), Luigi Naldini(Vita-Salute San Raffaele University), Stefano Beretta(The San Raffaele Telethon Institute for Gene Therapy), Barbara Camisa(Vita-Salute San Raffaele University), Lucia Sergi Sergi(The San Raffaele Telethon Institute for Gene Therapy), Chiara Iozzi(Vita-Salute San Raffaele University), Alessia Airaghi(Vita-Salute San Raffaele University), Tonon(Vita-Salute San Raffaele University), Giulio Giovannoni(Vita-Salute San Raffaele University), Alessia Ugolini(Vita-Salute San Raffaele University), Michele Reni(Vita-Salute San Raffaele University), Alice Grometto(Vita-Salute San Raffaele University), Martina Fiumara(The San Raffaele Telethon Institute for Gene Therapy), Giulio Belfiori(Vita-Salute San Raffaele University)
Nature Communications
January 8, 2026
Cited by 2


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