Detection and localization of surgically resectable cancers with a multi-analyte blood test

Joshua D. Cohen(Howard Hughes Medical Institute), Lu Li(Johns Hopkins University), Yuxuan Wang(Howard Hughes Medical Institute), Christopher J. Thoburn(Johns Hopkins University), Bahman Afsari(Johns Hopkins University), Ludmila Danilova(Johns Hopkins University), Christopher Douville(Howard Hughes Medical Institute), Ammar A. Javed(Johns Hopkins University), Fay Wong(Johns Hopkins University), Austin K. Mattox(Howard Hughes Medical Institute), Ralph H. Hruban(Johns Hopkins University), Christopher L. Wolfgang(Johns Hopkins University), Michael Goggins(Johns Hopkins University), Marco Dal Molin(Johns Hopkins University), Tian‐Li Wang(Johns Hopkins University), Richard B.S. Roden(Johns Hopkins University), Alison P. Klein(Johns Hopkins University), Janine Ptak(Howard Hughes Medical Institute), Lisa Dobbyn(Johns Hopkins University), Joy Schaefer(Johns Hopkins University), Natalie Silliman(Howard Hughes Medical Institute), Maria Popoli(Johns Hopkins University), Joshua T Vogelstein(Johns Hopkins University), J. Dale Browne(Johns Hopkins University), Robert E. Schoen(University of Pittsburgh), Randall E. Brand(University of Pittsburgh), Jeanne Tie(The University of Melbourne), Peter Gibbs(The University of Melbourne), Hui‐Li Wong(Walter and Eliza Hall Institute of Medical Research), Aaron S. Mansfield(Mayo Clinic in Arizona), Jin Jen(Mayo Clinic), Samir Hanash(The University of Texas MD Anderson Cancer Center), Massimo Falconi(Vita-Salute San Raffaele University), Peter J. Allen(Memorial Sloan Kettering Cancer Center), Shibin Zhou(Johns Hopkins University), Chetan Bettegowda(Johns Hopkins University), Luis A. Díaz(Johns Hopkins University), Cristian Tomasetti(Johns Hopkins University), Kenneth W. Kinzler(Johns Hopkins University), Bert Vogelstein(Howard Hughes Medical Institute), Anne Marie Lennon(Johns Hopkins University), Nickolas Papadopoulos(Johns Hopkins University)
Science
January 18, 2018
10.1126/science.aar3247
Cited by 2,781

Abstract

Earlier detection is key to reducing cancer deaths. Here, we describe a blood test that can detect eight common cancer types through assessment of the levels of circulating proteins and mutations in cell-free DNA. We applied this test, called CancerSEEK, to 1005 patients with nonmetastatic, clinically detected cancers of the ovary, liver, stomach, pancreas, esophagus, colorectum, lung, or breast. CancerSEEK tests were positive in a median of 70% of the eight cancer types. The sensitivities ranged from 69 to 98% for the detection of five cancer types (ovary, liver, stomach, pancreas, and esophagus) for which there are no screening tests available for average-risk individuals. The specificity of CancerSEEK was greater than 99%: only 7 of 812 healthy controls scored positive. In addition, CancerSEEK localized the cancer to a small number of anatomic sites in a median of 83% of the patients.

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