Integrated single-cell and spatial transcriptomics uncover distinct cellular subtypes involved in neural invasion in pancreatic cancer
Minmin Chen(Shenzhen Bay Laboratory), Qinhang Gao(Center for Life Sciences), Huiheng Ning(Shenzhen Bay Laboratory), Kang Chen(Shenzhen Bay Laboratory), Yang Gao(Shenzhen Bay Laboratory), Min Yu(Guangdong Academy of Medical Sciences), Chaoqun Liu(Guangdong Academy of Medical Sciences), Wei Zhou(Shenzhen Bay Laboratory), Jieying Pan(Shenzhen Bay Laboratory), Lusheng Wei(Guangdong Academy of Medical Sciences), Wenxian Dou(Guangdong Academy of Medical Sciences), Dingwen Zhang(Guangdong Academy of Medical Sciences), Linnan Zhu(Peking University), Qinglin Zhang(Guangdong Academy of Medical Sciences), Rufu Chen(Guangdong Academy of Medical Sciences), Zemin Zhang(Peking University)
Cited by 61Open Access
Abstract
Schwann cells locate at the leading edge of NI, can be induced by transforming growth factor β (TGF-β) signaling, promote tumor cell migration, and correlate with poor survival. We also identify basal-like and neural-reactive malignant subpopulations with distinct morphologies and heightened NI potential. This landscape depicting tumor-associated nerves highlights critical cancer-immune-neural interactions in situ and enlightens treatment development targeting NI.
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