Senescence and inflammation are unintended adverse consequences of CRISPR-Cas9/AAV6-mediated gene editing in hematopoietic stem cells

Anastasia Conti(The San Raffaele Telethon Institute for Gene Therapy), Raffaella Di Micco(The San Raffaele Telethon Institute for Gene Therapy)

Cell Reports Medicine

June 1, 2025

10.1016/j.xcrm.2025.102157

Cited by 7

Related Papers

Cellular and transcriptional dynamics of human neutrophils at steady state and upon stress

|Nature Immunology|2022|203

An early‐senescence state in aged mesenchymal stromal cells contributes to hematopoietic stem and progenitor cell clonogenic impairment through the activation of a pro‐inflammatory program

|Aging Cell|2019|173

Mechanisms of hematopoietic clonal dominance in VEXAS syndrome

|Nature Medicine|2025|38

Unraveling Pathophysiology and Hematopoiesis of Vexas Syndrome By Multi-Omics Analyses and Targeted Gene Editing

|Blood|2023|2

Poisoning of Healthy Hematopoiesis Is an Unanticipated Mechanism Driving Clonal Dominance in Vexas Syndrome

|Blood|2024|1