13P A novel H&E-based classification of tertiary lymphoid structures in breast cancer

E. Seguí Solís(Breast Cancer Research Foundation), Anabel Martínez-Romero(Breast Cancer Research Foundation), F. Brasó-Maristany(Breast Cancer Research Foundation), T. Pascual(Breast Cancer Research Foundation), M. Marin(Oryzon Genomics (Spain)), R. Gómez Bravo(Breast Cancer Research Foundation), I. Garcia Fructuoso(Breast Cancer Research Foundation), A. Rodriguez Hernandez(Breast Cancer Research Foundation), Olga Martínez‐Sáez(Breast Cancer Research Foundation), P. Galván(Breast Cancer Research Foundation), C. Saura Manich(Hebron University), E.M. Ciruelos(Hospital Universitario 12 De Octubre), AG Waks(Dana-Farber Cancer Institute), S.M. Tolaney(Dana-Farber Cancer Institute), M. Oliveira(Vall d'Hebron Hospital Universitari), L. Pare Brunet(Oryzon Genomics (Spain)), J.M. Ferrero-Cafiero(Solti), A. Prat(Breast Cancer Research Foundation), E. Sanfeliu Torres(Hospital Clínic de Barcelona)
ESMO Open
May 1, 2025
10.1016/j.esmoop.2025.104567
Cited by 0Open Access
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Abstract

Tertiary lymphoid structures (TLS) drive adaptive antitumor immunity, impacting prognosis and immunotherapy efficacy across cancers. However, no established classification exists for TLS in breast cancer (BC). This study aims to define a novel hematoxylin and eosin (H&E)-based TLS scoring system in BC and identify gene expression-based biology indicative of TLS presence.

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