Discovery of a Potent and Selective Protein Arginine Methyltransferase 5 (PRMT5) PROTAC Degrader

Yue Zhong(Icahn School of Medicine at Mount Sinai), Jian Jin(Icahn School of Medicine at Mount Sinai)
Journal of Medicinal Chemistry
April 15, 2025
10.1021/acs.jmedchem.5c00198
Cited by 9

Related Papers

The promise and peril of chemical probes
|Nature Chemical Biology|2015|848
A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases
|ACS Chemical Biology|2015|290
Gain-of-Function Genetic Alterations of G9a Drive Oncogenesis
|Cancer Discovery|2020|73
Acetylation Targeting Chimera Enables Acetylation of the Tumor Suppressor p53
|Journal of the American Chemical Society|2023|53
Discovery of Potent and Selective WDR5 Proteolysis Targeting Chimeras as Potential Therapeutics for Pancreatic Cancer
|Journal of Medicinal Chemistry|2023|50