Discovery of Potent and Selective WDR5 Proteolysis Targeting Chimeras as Potential Therapeutics for Pancreatic Cancer

Xufen Yu(Icahn School of Medicine at Mount Sinai), Jian Jin(Icahn School of Medicine at Mount Sinai)
Journal of Medicinal Chemistry
November 29, 2023
10.1021/acs.jmedchem.3c01521
Cited by 50

Related Papers

A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases
|ACS Chemical Biology|2015|290
Acetylation Targeting Chimera Enables Acetylation of the Tumor Suppressor p53
|Journal of the American Chemical Society|2023|53
Discovery of a novel, highly potent EZH2 PROTAC degrader for targeting non-canonical oncogenic functions of EZH2
|European Journal of Medicinal Chemistry|2024|36
Targeted Degradation of PRC1 Components, BMI1 and RING1B, via a Novel Protein Complex Degrader Strategy
|Advanced Science|2023|25
Dissecting and targeting noncanonical functions of EZH2 in multiple myeloma via an EZH2 degrader
|Oncogene|2023|25