Mutational and co-mutational landscape of early onset colorectal cancer
Jumanah Alshenaifi(The University of Texas MD Anderson Cancer Center), Guglielmo Vetere(The University of Texas MD Anderson Cancer Center), Giulia Maddalena(The University of Texas MD Anderson Cancer Center), Mahmoud Yousef(The University of Texas MD Anderson Cancer Center), Michael G. White(The University of Texas MD Anderson Cancer Center), John Paul Shen(The University of Texas MD Anderson Cancer Center), Eduardo Vilar(The University of Texas MD Anderson Cancer Center), Christine M. Parseghian(The University of Texas MD Anderson Cancer Center), Arvind Dasari(The University of Texas MD Anderson Cancer Center), Van K. Morris(The University of Texas MD Anderson Cancer Center), Ryan Huey(The University of Texas MD Anderson Cancer Center), Michael J. Overman(The University of Texas MD Anderson Cancer Center), Robert A. Wolff(The University of Texas MD Anderson Cancer Center), Kanwal Raghav(The University of Texas MD Anderson Cancer Center), Jason Willis(The University of Texas MD Anderson Cancer Center), Kristin D Alfaro(The University of Texas MD Anderson Cancer Center), Andy Futreal(The University of Texas MD Anderson Cancer Center), Y. Nancy You(The University of Texas MD Anderson Cancer Center), Scott Kopetz(The University of Texas MD Anderson Cancer Center)
Cited by 21Open Access
Abstract
INTRODUCTION: Colorectal cancer (CRC) incidence and mortality before 50 have been rising alarmingly in the recent decades. METHODS: Using a cohort of 10,000 patients, this study investigates the clinical, mutational, and co-mutational features of CRC in early-onset (EOCRC, < 50 years) compared to late-onset (LOCRC, ≥ 50 years). RESULTS: . CONCLUSION: This study highlights the significance of age-specific molecular profiling, offering insights into the unique biology of EOCRC and potential clinical applications.
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