Neuronal downregulation of PLCG2 impairs synaptic function and elicits Alzheimer disease hallmarks

Jean‐Charles Lambert; Julie Dumont; Marc Hulsman; John C. van Swieten; Mari Takalo; Alejandra Freire‐Regatillo; Audrey Coulon; John Hardy; Heli Jeskanen; Henna Martiskainen; Alfredo Ramı́rez; Philippe Amouyel; Tuomas Rauramaa; Rebecca Sims; Dolores Siedlecki‐Wullich; Michael Wagner; Erwan Lambert; Henne Holstege; Julie Williams; Séverine Deforges; Teemu Kuulasmaa; Roosa-Maria Willman; Céline Bellenguez; Julien Chapuis; Sami Heikkinen; Avishek Roy; Christophe Mulle; Hilkka Soininen; Devrim Kilinc; Tiago Mendes; Mikko Hiltunen; Oriol Dols‐Icardo; Gaël Nicolas; Aarno Palotie; Simon Mead; Marcos R. Costa; Chloé Najdek; Carla Gelle; Nina lannette-Weimann; Célia Lemeu; Florian Rabiller; Florie Delmiautte; petra makinen; Mitja Kurki; Anaël Erhardt; Ana Melo de Farias; lukas-iohan carvalho; Anne‐Marie Ayral; Benjamin Grenier‐Boley; Camille Charbonnier

doi:10.21203/rs.3.rs-4437808/v1

Neuronal downregulation of PLCG2 impairs synaptic function and elicits Alzheimer disease hallmarks

Jean‐Charles Lambert(Inserm), Julie Dumont(Inserm), Marc Hulsman(Amsterdam UMC Location Vrije Universiteit Amsterdam), John C. van Swieten(Erasmus MC), Mari Takalo(University of Eastern Finland), Alejandra Freire‐Regatillo(Institut Pasteur de Lille), Audrey Coulon(Inserm), John Hardy(National Hospital for Neurology and Neurosurgery), Heli Jeskanen(University of Eastern Finland), Henna Martiskainen(University of Eastern Finland), Alfredo Ramı́rez(University of Cologne), Philippe Amouyel(Institut Pasteur de Lille), Tuomas Rauramaa(University of Eastern Finland), Rebecca Sims(Cardiff University), Dolores Siedlecki‐Wullich(Inserm), Michael Wagner(University of Bonn), Erwan Lambert(Inserm), Henne Holstege(Amsterdam Neuroscience), Julie Williams(MACOM (United States)), Séverine Deforges(Université de Bordeaux), Teemu Kuulasmaa(University of Eastern Finland), Roosa-Maria Willman(University of Eastern Finland), Céline Bellenguez(Inserm), Julien Chapuis(Inserm), Sami Heikkinen(University of Eastern Finland), Avishek Roy(Centre National de la Recherche Scientifique), Christophe Mulle(Centre National de la Recherche Scientifique), Hilkka Soininen, Devrim Kilinc(Inserm), Tiago Mendes(Inserm), Mikko Hiltunen(University of Eastern Finland), Oriol Dols‐Icardo(Universitat Autònoma de Barcelona), Gaël Nicolas(Inserm), Aarno Palotie(Broad Institute), Simon Mead(Broad Institute), Marcos R. Costa(Universidade Federal do Rio Grande do Norte), Chloé Najdek(Inserm), Carla Gelle(Inserm), Nina lannette-Weimann(Institut Pasteur de Lille), Célia Lemeu(Institut Pasteur de Lille), Florian Rabiller(Institut Pasteur de Lille), Florie Delmiautte(Institut Pasteur de Lille), petra makinen(University of Eastern Finland), Mitja Kurki(Massachusetts General Hospital), Anaël Erhardt(Centre National de la Recherche Scientifique), Ana Melo de Farias(Institut Pasteur de Lille), lukas-iohan carvalho(Institut Pasteur de Lille), Anne‐Marie Ayral(Inserm), Benjamin Grenier‐Boley(University of Bonn), Camille Charbonnier(Université de Rouen Normandie)

Research Square

May 31, 2024

10.21203/rs.3.rs-4437808/v1

Cited by 1

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