Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 That Exhibits Antiviral Efficacy in SARS-CoV-2-Infected African Green Monkeys

Richard L. Mackman(Gilead Sciences (United States)), Tomáš Cihlář(Gilead Sciences (United States)), Andrea Ambrosi(Gilead Sciences (United States)), Renmeng Liu(University of Oklahoma), Kassibla Elodie Dempah(Gilead Sciences (United States)), Tien-Ying Hsiang(University of Washington), Xianghan Lu(United States Military Academy), Raju Subramanian(Gilead Sciences (United States)), Joy Y. Feng(Gilead Sciences (United States)), Anita Niedziela‐Majka(Gilead Sciences (United States)), Charlotte Hedskog(Gilead Sciences (United States)), Darius Babusis(Gilead Sciences (United States)), Justin Dearing(Lovelace Respiratory Research Institute), Blake J. Bleier(Gilead Sciences (United States)), Michael Gale(University of Washington), Venice Du Pont(Gilead Sciences (United States)), Meredith Cook(Gilead Sciences (United States)), Michael Lee(Ames Research Center), Jasmine Moshiri(Gilead Sciences (United States)), Kimberly T. Barrett(Gilead Sciences (United States)), Nicholas C. Riola(Gilead Sciences (United States)), Meghan S. Vermillion(Lovelace Respiratory Research Institute), B. Michael O’Keefe(Gilead Sciences (United States)), Yili Xu(Yanshan University), John P. Bilello(Global Vaccines (United States)), Anh-Quan Nguyen(Gilead Sciences (United States)), Ashley Davie(Gilead Sciences (United States)), Rao Kalla(Gilead Sciences (United States)), Gary Lee(Sir Charles Gairdner Hospital), Lauren Rodriguez(Gilead Sciences (United States)), Jared Pitts(Gilead Sciences (United States)), Joy Yu(Gilead Sciences (United States)), Kwon Soo Chun(Gilead Sciences (United States)), Elaine Bunyan(Gilead Sciences (United States))
Journal of Medicinal Chemistry
August 19, 2023
Cited by 63


Related Papers