Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy

Krzysztof Kiryluk; Elena Sánchez; Shu‐Feng Zhou; Francesca Zanoni; Lili Liu; Nikol Mladkova; Atlas Khan; Maddalena Marasà; Jun Y. Zhang; Olivia Balderes; Simone Sanna‐Cherchi; Andrew S. Bomback; Pietro A. Canetta; Gerald B. Appel; Jai Radhakrishnan; Hernán Trimarchi; Ben Sprangers; Daniel Cattran; Heather N. Reich; York Pei; Pietro Ravani; Kres̆imir Gales̃ić; Dita Maixnerová; Vladimı́r Tesař; Bénédicte Stengel; Marie Metzger; Guillaume Canaud; Nicolas Maillard; F. Berthoux; Laureline Berthelot; Évangéline Pillebout; Renato C. Monteiro; Raoul D. Nelson; Robert Wyatt; William E. Smoyer; John D. Mahan; Al-Akash Samhar; Guillermo Hidalgo; Alejandro Quiroga; Patricia L. Weng; Raji Sreedharan; David T. Selewski; Keefe Davis; Mahmoud Kallash; Tetyana L. Vasylyeva; Michelle N. Rheault; Aftab S. Chishti; Daniel Ranch; Scott E. Wenderfer; Dmitry Samsonov; Donna Claes; Oleh M. Akchurin; Dimitrios Goumenos; Μaria Stangou; Judit Nagy; Tibor Kovács; Enrico Fiaccadori; Antonio Amoroso; Cristina Barlassina; Daniele Cusi; Lucia Del Vecchio; Giovanni Giorgio Battaglia; Monica Bodria; Emanuela Boer; Luisa Bono; Giuliano Boscutti; Gianluca Caridi; Francesca Lugani; Gian Marco Ghiggeri; Rosanna Coppo; Licia Peruzzi; Vittoria Esposito; Ciro Esposito; Sandro Feriozzi; Rosaria Polci; Giovanni M. Frascà; Marco Galliani; Maurizio Garozzo; Adele Mitrotti; Loreto Gesualdo; Simona Granata; Gianluigi Zaza; Francesco Londrino; Riccardo Magistroni; Isabella Pisani; Andrea Magnano; Carmelita Marcantoni; Piergiorgio Messa; Renzo Mignani; Antonello Pani; Claudio Ponticelli; Dario Roccatello; Maurizio Salvadori; Erica Salvi; Domenico Santoro; Guido Gembillo; Silvana Savoldi; Donatella Spotti; Pasquale Zamboli; Claudia Izzi; Federico Alberici; Elisa Delbarba; Michał Florczak; Natalia Krata; Krzysztof Mucha; Leszek Pączek; Stanisław Niemczyk; Barbara Moszczuk; Małgorzata Pańczyk-Tomaszewska; Małgorzata Mizerska-Wasiak; Agnieszka Perkowska‐Ptasińska; Teresa Bączkowska; Magdalena Durlik; Krzysztof Pawlaczyk; Przemysław Sikora; Marcin Zaniew; Dorota Kamińska; Magdalena Krajewska; Izabella Kuźmiuk-Glembin; Zbigniew Heleniak; Barbara Bułło‐Piontecka; Tomasz Liberek; Alicja Dębska‐Ślizień; Tomasz Hryszko; Anna Materna‐Kiryluk; Monika Miklaszewska; Maria Szczepańska; Katarzyna Dyga; Edyta Machura; Katarzyna Siniewicz‐Luzeńczyk; Monika Pawlak-Bratkowska; Marcin Tkaczyk; Dariusz Runowski; Norbert Kwella; Dorota Drożdż; Ireneusz Habura; Florian Kronenberg; Larisa Prikhodina; David A. van Heel; Bertrand Fontaine; Chris Cotsapas; Cisca Wijmenga; André Franke; Vito Annese; Peter K. Gregersen; Sreeja Parameswaran; Matthew T. Weirauch; Leah C. Kottyan; John B. Harley; Hitoshi Suzuki; Ichiei Narita; Shin Goto; Hajeong Lee; Dong Ki Kim; Yon Su Kim; Jin‐Ho Park; Belong Cho; Murim Choi; Ans Van Wijk; Ana Huerta; Elisabet Ars; José Ballarín; Sigrid Lundberg; Bruno Vogt; Laila‐Yasmin Mani; Yaşar Çalışkan; Jonathan Barratt; Thilini Abeygunaratne; Philip A. Kalra; Daniel P. Gale; Ulf Panzer; Thomas Rauen; Jürgen Floege; Pascal Schlosser; Arif B. Ekici; Kai‐Uwe Eckardt; Nan Chen; Jingyuan Xie; Richard P. Lifton; Ruth J. F. Loos; Eimear E. Kenny; Iuliana Ionita‐Laza; Anna Köttgen; Bruce A. Julian; Jan Novák; Francesco Scolari; Hong Zhang; Ali G. Gharavi

doi:10.1038/s41588-023-01422-x

Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy

Krzysztof Kiryluk(New York Genome Center), Elena Sánchez(Columbia University), Shu‐Feng Zhou(Peking University), Francesca Zanoni(Columbia University), Lili Liu(Columbia University), Nikol Mladkova(Columbia University), Atlas Khan(Columbia University), Maddalena Marasà(Columbia University), Jun Y. Zhang(Columbia University), Olivia Balderes(Columbia University), Simone Sanna‐Cherchi(Columbia University), Andrew S. Bomback(Columbia University), Pietro A. Canetta(Columbia University), Gerald B. Appel(Columbia University), Jai Radhakrishnan(Columbia University), Hernán Trimarchi(Hospital Británico de Buenos Aires), Ben Sprangers(KU Leuven), Daniel Cattran(University of Toronto), Heather N. Reich(University of Toronto), York Pei(University of Toronto), Pietro Ravani(University of Calgary), Kres̆imir Gales̃ić(Zagreb School of Business), Dita Maixnerová(Charles University), Vladimı́r Tesař(Charles University), Bénédicte Stengel(Inserm), Marie Metzger(Inserm), Guillaume Canaud(Hôpital Necker-Enfants Malades), Nicolas Maillard, F. Berthoux, Laureline Berthelot, Évangéline Pillebout(Centre National de la Recherche Scientifique), Renato C. Monteiro(Centre National de la Recherche Scientifique), Raoul D. Nelson(University of Utah), Robert Wyatt(University of Tennessee Health Science Center), William E. Smoyer(Nationwide Children's Hospital), John D. Mahan(Nationwide Children's Hospital), Al-Akash Samhar(Driscoll Children's Hospital), Guillermo Hidalgo(Hackensack University Medical Center), Alejandro Quiroga(Helen DeVos Children's Hospital), Patricia L. Weng(Mattel Children's Hospital), Raji Sreedharan(Medical College of Wisconsin), David T. Selewski(C. S. Mott Children's Hospital), Keefe Davis(Medical University of South Carolina), Mahmoud Kallash(University at Buffalo, State University of New York), Tetyana L. Vasylyeva(Nationwide Children's Hospital), Michelle N. Rheault(University of Minnesota), Aftab S. Chishti(University of Kentucky), Daniel Ranch(University of Kentucky), Scott E. Wenderfer(Baylor College of Medicine), Dmitry Samsonov(Boston Children's Hospital), Donna Claes(New York Medical College), Oleh M. Akchurin(Cornell University), Dimitrios Goumenos(Aristotle University of Thessaloniki), Μaria Stangou(Aristotle University of Thessaloniki), Judit Nagy(University of Pecs), Tibor Kovács(University of Pecs), Enrico Fiaccadori(University of Parma), Antonio Amoroso(University of Turin), Cristina Barlassina(University of Milan), Daniele Cusi(University of Milan), Lucia Del Vecchio(Azienda Socio Sanitaria Territoriale Lariana), Giovanni Giorgio Battaglia, Monica Bodria(University of Messina), Emanuela Boer(Istituto di Sociologia Internazionale di Gorizia), Luisa Bono(Azienda di Rilievo Nazionale ed Alta Specializzazione), Giuliano Boscutti(Ospedale Santa Maria della Misericordia di Udine), Gianluca Caridi(Istituto Giannina Gaslini), Francesca Lugani(Istituto Giannina Gaslini), Gian Marco Ghiggeri(Istituto Giannina Gaslini), Rosanna Coppo(Ospedale Regina Margherita), Licia Peruzzi(Ospedale Regina Margherita), Vittoria Esposito(University of Pavia), Ciro Esposito(University of Pavia), Sandro Feriozzi(Ospedale di Belcolle), Rosaria Polci(Ospedale di Belcolle), Giovanni M. Frascà(Ospedali Riuniti di Ancona), Marco Galliani(Ospedale Sandro Pertini), Maurizio Garozzo, Adele Mitrotti(University of Bari Aldo Moro), Loreto Gesualdo(University of Bari Aldo Moro), Simona Granata(University of Verona), Gianluigi Zaza(University of Verona), Francesco Londrino(CTO Andrea Alesini), Riccardo Magistroni(University of Modena and Reggio Emilia), Isabella Pisani(University of Parma), Andrea Magnano(University of Parma), Carmelita Marcantoni, Piergiorgio Messa(University of Milan), Renzo Mignani(Azienda Unità Sanitaria Locale Rimini), Antonello Pani(Azienda Ospedaliera G. Brotzu), Claudio Ponticelli(Ospedale Maggiore), Dario Roccatello(Ospedale San Giovanni Bosco), Maurizio Salvadori, Erica Salvi(University of Milan), Domenico Santoro(University of Messina), Guido Gembillo(University of Messina), Silvana Savoldi(CTO Hospital), Donatella Spotti, Pasquale Zamboli, Claudia Izzi(University of Brescia), Federico Alberici(University of Brescia), Elisa Delbarba(University of Brescia), Michał Florczak(Medical University of Warsaw), Natalia Krata(Medical University of Warsaw), Krzysztof Mucha(Medical University of Warsaw), Leszek Pączek(Medical University of Warsaw), Stanisław Niemczyk(Wojskowy Instytut Medycyny Lotniczej), Barbara Moszczuk(Medical University of Warsaw), Małgorzata Pańczyk-Tomaszewska(Medical University of Warsaw), Małgorzata Mizerska-Wasiak(Medical University of Warsaw), Agnieszka Perkowska‐Ptasińska(Medical University of Warsaw), Teresa Bączkowska(Medical University of Warsaw), Magdalena Durlik(Medical University of Warsaw), Krzysztof Pawlaczyk(Poznan University of Medical Sciences), Przemysław Sikora(Medical University of Lublin), Marcin Zaniew(University of Zielona Góra), Dorota Kamińska(Wroclaw Medical University), Magdalena Krajewska(Wroclaw Medical University), Izabella Kuźmiuk-Glembin(Gdańsk Medical University), Zbigniew Heleniak(Gdańsk Medical University), Barbara Bułło‐Piontecka(Gdańsk Medical University), Tomasz Liberek(Gdańsk Medical University), Alicja Dębska‐Ślizień(Gdańsk Medical University), Tomasz Hryszko(Medical University of Białystok), Anna Materna‐Kiryluk(Poznan University of Medical Sciences), Monika Miklaszewska(Jagiellonian University), Maria Szczepańska(Medical University of Silesia), Katarzyna Dyga(Medical University of Silesia), Edyta Machura(Medical University of Silesia), Katarzyna Siniewicz‐Luzeńczyk(Polish Mother’s Memorial Hospital Research Institute), Monika Pawlak-Bratkowska(Polish Mother’s Memorial Hospital Research Institute), Marcin Tkaczyk(Polish Mother’s Memorial Hospital Research Institute), Dariusz Runowski(Children's Memorial Health Institute), Norbert Kwella(University of Warmia and Mazury in Olsztyn), Dorota Drożdż(Jagiellonian University), Ireneusz Habura(Grochowski Hospital), Florian Kronenberg(Innsbruck Medical University), Larisa Prikhodina(Pirogov Russian National Research Medical University), David A. van Heel(Queen Mary University of London), Bertrand Fontaine(Inserm), Chris Cotsapas(Yale University), Cisca Wijmenga(University of Groningen), André Franke(Christian-Albrechts-Universität zu Kiel), Vito Annese, Peter K. Gregersen(Northwell Health), Sreeja Parameswaran(Cincinnati Children's Hospital Medical Center), Matthew T. Weirauch(Cincinnati Children's Hospital Medical Center), Leah C. Kottyan(Cincinnati Children's Hospital Medical Center), John B. Harley(United States Department of Veterans Affairs), Hitoshi Suzuki(Juntendo University), Ichiei Narita(Niigata University), Shin Goto(Niigata University), Hajeong Lee(Seoul National University), Dong Ki Kim(Seoul National University), Yon Su Kim(Seoul National University), Jin‐Ho Park(Seoul National University Hospital), Belong Cho(Seoul National University), Murim Choi(Seoul National University), Ans Van Wijk(Amsterdam UMC Location Vrije Universiteit Amsterdam), Ana Huerta(Instituto de Salud Carlos III), Elisabet Ars(Universitat Autònoma de Barcelona), José Ballarín(Universitat Autònoma de Barcelona), Sigrid Lundberg(Karolinska Institutet), Bruno Vogt(University of Bern), Laila‐Yasmin Mani(University of Bern), Yaşar Çalışkan(Saint Louis University), Jonathan Barratt, Thilini Abeygunaratne(Salford Royal Hospital), Philip A. Kalra(Salford Royal Hospital), Daniel P. Gale(University College London), Ulf Panzer(Universität Hamburg), Thomas Rauen(RWTH Aachen University), Jürgen Floege(RWTH Aachen University), Pascal Schlosser(University of Freiburg), Arif B. Ekici(Friedrich-Alexander-Universität Erlangen-Nürnberg), Kai‐Uwe Eckardt(Friedrich-Alexander-Universität Erlangen-Nürnberg), Nan Chen(Ruijin Hospital), Jingyuan Xie(Ruijin Hospital), Richard P. Lifton(Yale University), Ruth J. F. Loos(University of Copenhagen), Eimear E. Kenny(Mount Sinai Health System), Iuliana Ionita‐Laza(Columbia University), Anna Köttgen(University of Freiburg), Bruce A. Julian(University of Alabama at Birmingham), Jan Novák(University of Alabama at Birmingham), Francesco Scolari(University of Brescia), Hong Zhang(Peking University), Ali G. Gharavi(Columbia University Irving Medical Center)

Nature Genetics

June 19, 2023

10.1038/s41588-023-01422-x

Cited by 166Open Access

Full Text

Abstract

Related Papers

No related papers found

Powered by citation graph analysis