SIRT3 mediates the effects of PCSK9 inhibitors on inflammation, autophagy, and oxidative stress in endothelial cells
Nunzia D’Onofrio, Francesco Prattichizzo(MultiMedica), Raffaele Marfella(University of Campania "Luigi Vanvitelli"), Celestino Sardu(University of Campania "Luigi Vanvitelli"), Elisa Martino, Lucia Scisciola(University of Campania "Luigi Vanvitelli"), Lorenza Marfella(University of Campania "Luigi Vanvitelli"), Rosalba La Grotta(MultiMedica), Chiara Frigé(MultiMedica), Giuseppe Paolisso(Clinica Mediterranea), Antonio Ceriello(MultiMedica), Maria Luisa Balestrieri
Cited by 90Open Access
Abstract
: Overall, these data suggest that PCSK9i bear intrinsic anti-inflammatory, anti-autophagic, and antioxidant properties in endothelial cells, and that these pleiotropic effects might be mediated, at least in part, by SIRT3. These results provide an additional mechanism supporting the emerging knowledge relative to the benefit of PCSK9i on CVD beyond LDL-lowering and uncover SIRT3 as a putative mediator of such pleiotropy.
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