Fusion of Fc domain to Factor IX (FIX) modulates the Th2 biased response to FIX and triggers Th1 immunity in hemophilia B treated mice.
Ditza Levin(Center for Biologics Evaluation and Research), Basil Golding(Center for Biologics Evaluation and Research), Erin Burch(Syngenta (United States)), Haiyan Jiang(Inner Mongolia Agricultural University), Zuben E. Sauna(Center for Biologics Evaluation and Research), H. A. Daniel Lagassé(Center for Biologics Evaluation and Research), Siyuan Tan(CRISPR Therapeutics (Switzerland)), Scott E. Strome(Northwestern Medicine Lake Forest Hospital)
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