Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood–Brain Barrier Penetrant PROTAC Degrader of Leucine-Rich Repeat Kinase 2
Xingui Liu(University of Dundee), Alexia F. Kalogeropulou(University of Dundee), Sofia Domingos(University of Dundee), Nikolai Makukhin(University of Dundee), Raja Sekhar Nirujogi(University of Dundee), François Singh(University of Dundee), Natalia Shpiro(University of Dundee), Anton Saalfrank(University of Dundee), Esther Sammler(University of Dundee), Ian G. Ganley(University of Dundee), Rui Moreira(University of Lisbon), Dario R. Alessi(University of Dundee), Alessio Ciulli(University of Dundee)
Cited by 170Open Access
Abstract
and offer an attractive starting point for future drug development.