Fluorine in medicinal chemistry
Sophie Purser(Oxford Research Group), Peter R. Moore(AstraZeneca (United Kingdom)), Steve Swallow(AstraZeneca (United Kingdom)), Véronique Gouverneur(Oxford Research Group)
Cited by 7,394
Abstract
It has become evident that fluorinated compounds have a remarkable record in medicinal chemistry and will play a continuing role in providing lead compounds for therapeutic applications. This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion clarifying the role and impact of fluorine substitution on drug potency.
Related Papers
No related papers found
Powered by citation graph analysis