Copper-Catalyzed Cross-Coupling of Alkyl and Phosphorus Radicals for C(sp<sup>3</sup>)–P Bond Formation

Chengkun Li(Soochow University), Ze‐Kun Tao(Soochow University), Adedamola Shoberu(Soochow University), Wei Zhang(University of Massachusetts Boston), Jian‐Ping Zou(Soochow University)
Organic Letters
August 11, 2022
Cited by 42

Abstract

A CuI-catalyzed cross-coupling of alkyl- and phosphorus-centered radicals for C(sp3)–P bond formation is introduced. Diacyl peroxides, generated in situ from aliphatic acids and H2O2, serve as a source for alkyl radicals and also an initiator for the generation of phosphorus radicals from H–P(O) compounds.


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