NUDT1 promotes the accumulation and longevity of CD103+ TRM cells in primary biliary cholangitis
Bingyuan Huang(Shanghai Jiao Tong University), Zhuwan Lyu(Shanghai Jiao Tong University), Qiwei Qian(Shanghai Jiao Tong University), Yong Chen(Shanghai Jiao Tong University), Jun Zhang(Shanghai Jiao Tong University), Bo Li(Shanghai Jiao Tong University), Yikang Li(Shanghai Jiao Tong University), Jubo Liang(Shanghai Jiao Tong University), Qiaoyan Liu(Shanghai Jiao Tong University), You Li(Shanghai Jiao Tong University), Ruiling Chen(Shanghai Jiao Tong University), Min Lian(Shanghai Jiao Tong University), Xiao Xiao(Shanghai Jiao Tong University), Qi Miao(Shanghai Jiao Tong University), Qixia Wang(Shanghai Jiao Tong University), Jing‐Yuan Fang(Shanghai Jiao Tong University), Zhe‐Xiong Lian(South China University of Technology), Yanmei Li(Shanghai Jiao Tong University), Ruqi Tang(Shanghai Jiao Tong University), Thomas Helleday(Science for Life Laboratory), M. Eric Gershwin(University of California, Davis), Zhengrui You(Shanghai Jiao Tong University), Xiong Ma(Shanghai Jiao Tong University)
Cited by 56Open Access
Abstract
BACKGROUND & AIMS: T-cell subpopulations and investigate their immunobiology in PBC. METHODS: cells in vivo was studied by 2-octynoic acid-BSA (2OA-BSA) immunization, Nudt1 conditional knock-out and adoptive co-transfer in a murine model. RESULTS: cell durable survival and TGFβ-Smad signaling. CONCLUSIONS: cell accumulation and longevity represents a novel therapeutic target in PBC. LAY SUMMARY: T cell subset, and worked out the mechanisms of its hyperactivation and longevity, which could be exploited therapeutically.
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