T

Thomas Helleday

Science for Life Laboratory

ORCID: 0000-0002-7384-092X

Publishes on DNA Repair Mechanisms, PARP inhibition in cancer therapy, CRISPR and Genetic Engineering. 688 papers and 35.9k citations.

688Publications

35.9kTotal Citations

DNA Repair Mechanisms PARP inhibition in cancer therapy CRISPR and Genetic Engineering Epigenetics and DNA Methylation Cancer-related Molecular Pathways

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Top publicationsby citations

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

Helen E. Bryant, Niklas Schultz, Huw D. Thomas et al.|Nature|2005

Cited by 5.2k

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

Jiřina Bártková, Nousin Rezaei, Michalis Liontos et al.|Nature|2006

Cited by 2k

DNA repair pathways as targets for cancer therapy

Thomas Helleday, Eva Petermann, Cecilia Lundin et al.|Nature reviews. Cancer|2008

Cited by 1.7k

Replication stress links structural and numerical cancer chromosomal instability

Rebecca A. Burrell, Sarah E. McClelland, David Endesfelder et al.|Nature|2013

Cited by 913Open Access

Mechanisms underlying mutational signatures in human cancers

Thomas Helleday, Saeed Eshtad, Serena Nik‐Zainal|Nature Reviews Genetics|2014

Cited by 876