Fat Transport in Lipoproteins — An Integrated Approach to Mechanisms and Disorders

Donald S. Fredrickson(National Heart Institute), Robert I. Levy(Institute of Molecular Medicine), Robert S. Lees(Rockefeller University)
New England Journal of Medicine
February 2, 1967
Cited by 748

Abstract

Type IV HyperlipoproteinemiaGeneral Definition. The Type IV lipoprotein pattern is the hallmark of endogenous hyperlipemia. It implies that glycerides synthesized in the body, usually in the liver, have been excreted into plasma at rates exceeding the capacity for removal. The appearance of a Type IV pattern often suggests that something has gone wrong with carbohydrate metabolism or caloric balance. There is evidence that it can sometimes mean inordinate emotional stress, excessive alcoholic intake or some other conflict between the patient and his environment. The development of this type of hyperlipoproteinemia is often conditioned by genotype.The Type IV . . .


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