Identifying biological themes within lists of genes with EASE
Douglas A Hosack(Science Applications International Corporation (United States)), Glynn Dennis(Science Applications International Corporation (United States)), Brad T. Sherman(Science Applications International Corporation (United States)), H. Clifford Lane(National Institutes of Health), Richard A. Lempicki(Science Applications International Corporation (United States))
Cited by 269Open Access
Abstract
EASE is a customizable software application for rapid biological interpretation of gene lists that result from the analysis of microarray, proteomics, SAGE, and other high-throughput genomic data. The biological themes returned by EASE recapitulate manually determined themes in previously published gene lists and are robust to varying methods of normalization, intensity calculation and statistical selection of genes. EASE is a powerful tool for rapidly converting the results of functional genomics studies from "genes to themes."
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