Identification of De Novo Pyrimidine Synthesis as a Targetable Vulnerability in a Novel IDH1 Mutant Engineered Astrocytoma Model
Derek Shi, Samuel K. McBrayer(The University of Texas Southwestern Medical Center), Keith L. Ligon(Brigham and Women's Hospital), Daniel P. Cahill(Harvard University), Michael M. Levitt(University of North Texas), Sabina Signoretti(Brigham and Women's Hospital), Jennifer E. Endress(Harvard University), Rebecca B. Jennings(IHS Markit (United States)), Isaac S. Harris(University of Rochester Medical Center), Andreas Sutter(Bayer (Germany)), Min Xu(Shanghai Institutes for Biological Sciences), Quang‐Dé Nguyen(Dana-Farber Cancer Institute), Januka Khanal(Brigham and Women's Hospital), Andreas Janzer(Bayer (Germany)), Kalil G. Abdullah(University of Pittsburgh), William G. Kaelin(Broad Institute), Wenhua Gao(Brigham and Women's Hospital), Stefan Gradl(Bayer (Germany)), Michael Jeffers(Sepragen Corporation (United States)), A.C. Wang(Harvard University)
International Journal of Radiation Oncology*Biology*Physics
October 25, 2021
Cited by 2
Related Papers
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O <sub>2</sub> Sensing
|Science|2001|4.7k
The landscape of somatic copy-number alteration across human cancers
|Nature|2010|4.1k
Patterns of somatic mutation in human cancer genomes
|Nature|2007|3.1k
Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein
|Nature Cell Biology|2000|1.6k