Comment on “Reintroduction of the archaic variant of <i>NOVA1</i> in cortical organoids alters neurodevelopment”
Tomislav Maričić(Max Planck Institute for Evolutionary Anthropology), Nelly Helmbrecht(Max Planck Institute for Evolutionary Anthropology), Stephan Riesenberg(Max Planck Institute for Evolutionary Anthropology), Dominik Macak(Max Planck Institute for Evolutionary Anthropology), Philipp Kanis(Max Planck Institute for Evolutionary Anthropology), Martin Lackner(Max Planck Institute for Evolutionary Anthropology), Agrafena Daria Pugach-Matveeva(Max Planck Institute for Evolutionary Anthropology), Svante Pääbo(Okinawa Institute of Science and Technology Graduate University)
Cited by 29
Abstract
. (Research Articles, 12 February 2021, eaax2537) conclude that the reintroduction of an ancestral amino acid substitution in the protein NOVA1 drastically alters the development of brain organoids. We show that cell lines used by the authors carry heterozygous deletions of the target DNA sequence, providing another plausible explanation for the effects observed.
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