A reservoir of stem-like CD8 <sup>+</sup> T cells in the tumor-draining lymph node preserves the ongoing antitumor immune response

Kelli A. Connolly; Manik Kuchroo; Aarthi Venkat; Achia Khatun; Jiawei Wang; Ivana William; Noah I. Hornick; Brittany Fitzgerald; Martina Damo; Moujtaba Y. Kasmani; Can Cui; Eric Fagerberg; Isabel Monroy; Amanda Hutchins; Julie F. Cheung; Gena G. Foster; Dylan L. Mariuzza; Mursal Nader; Hongyu Zhao; Weiguo Cui; Smita Krishnaswamy; Nikhil S. Joshi

doi:10.1126/sciimmunol.abg7836

A reservoir of stem-like CD8 <sup>+</sup> T cells in the tumor-draining lymph node preserves the ongoing antitumor immune response

Kelli A. Connolly(Yale University), Manik Kuchroo(Yale University), Aarthi Venkat(Yale University), Achia Khatun(Medical College of Wisconsin), Jiawei Wang(Yale University), Ivana William(Yale University), Noah I. Hornick(Yale University), Brittany Fitzgerald(Yale University), Martina Damo(Yale University), Moujtaba Y. Kasmani(Medical College of Wisconsin), Can Cui(Yale University), Eric Fagerberg(Yale University), Isabel Monroy(Yale University), Amanda Hutchins(Yale University), Julie F. Cheung(Yale University), Gena G. Foster(Yale University), Dylan L. Mariuzza(Yale University), Mursal Nader(Yale University), Hongyu Zhao(Yale University), Weiguo Cui(Medical College of Wisconsin), Smita Krishnaswamy(Yale University), Nikhil S. Joshi(Yale University)

Science Immunology

September 2, 2021

10.1126/sciimmunol.abg7836

Cited by 359Open Access

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Abstract

reservoir has a critical function in sustaining antitumor T cells during tumor development and in protecting them from the terminal differentiation that occurs in the TME.

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