Von Hippel–Lindau (VHL) small-molecule inhibitor binding increases stability and intracellular levels of VHL protein
Julianty Frost(University of Liverpool), Alessio Ciulli(University of Dundee)
Cited by 37
Related Papers
Structural basis of PROTAC cooperative recognition for selective protein degradation
|Nature Chemical Biology|2017|1.2k
Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4
|ACS Chemical Biology|2015|1k
BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
|Nature Chemical Biology|2019|571
Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel–Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7
|Journal of Medicinal Chemistry|2018|330
Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition
|Nature Communications|2016|241