BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design

William Farnaby; Manfred Koegl; Michael J. Roy; Claire Whitworth; Emelyne Diers; Nicole Trainor; David Zollman; Steffen Steurer; Jale Karolyi‐Oezguer; Carina Riedmueller; Teresa Gmaschitz; Johannes Wachter; Christian Dank; Michael Galant; Bernadette Sharps; Klaus Rumpel; Elisabeth Traxler; Thomas Gerstberger; Renate Schnitzer; Oliver Petermann; Peter Greb; Harald Weinstabl; Gerd Bader; Andreas Zoephel; A. Weiss-Puxbaum; Katharina Ehrenhöfer-Wölfer; Simon Wöhrle; Guido Boehmelt; Joerg Rinnenthal; Heribert Arnhof; Nicola Wiechens; Mengying Wu; Tom Owen‐Hughes; Peter Ettmayer; Mark Pearson; Darryl B. McConnell; Alessio Ciulli

doi:10.1038/s41589-019-0294-6

BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design

William Farnaby(University of Dundee), Manfred Koegl(Boehringer Ingelheim (Austria)), Michael J. Roy(University of Dundee), Claire Whitworth(University of Dundee), Emelyne Diers(University of Dundee), Nicole Trainor(University of Dundee), David Zollman(University of Dundee), Steffen Steurer(Boehringer Ingelheim (Austria)), Jale Karolyi‐Oezguer(Boehringer Ingelheim (Austria)), Carina Riedmueller(Boehringer Ingelheim (Austria)), Teresa Gmaschitz(Boehringer Ingelheim (Austria)), Johannes Wachter(Boehringer Ingelheim (Austria)), Christian Dank(Boehringer Ingelheim (Austria)), Michael Galant(Boehringer Ingelheim (Austria)), Bernadette Sharps(Boehringer Ingelheim (Austria)), Klaus Rumpel(Boehringer Ingelheim (Austria)), Elisabeth Traxler(Boehringer Ingelheim (Austria)), Thomas Gerstberger(Boehringer Ingelheim (Austria)), Renate Schnitzer(Boehringer Ingelheim (Austria)), Oliver Petermann(Boehringer Ingelheim (Austria)), Peter Greb(Boehringer Ingelheim (Austria)), Harald Weinstabl(Boehringer Ingelheim (Austria)), Gerd Bader(Boehringer Ingelheim (Austria)), Andreas Zoephel(Boehringer Ingelheim (Austria)), A. Weiss-Puxbaum(Boehringer Ingelheim (Austria)), Katharina Ehrenhöfer-Wölfer(Boehringer Ingelheim (Austria)), Simon Wöhrle(Boehringer Ingelheim (Austria)), Guido Boehmelt(Boehringer Ingelheim (Austria)), Joerg Rinnenthal(Boehringer Ingelheim (Austria)), Heribert Arnhof(Boehringer Ingelheim (Austria)), Nicola Wiechens(University of Dundee), Mengying Wu(University of Dundee), Tom Owen‐Hughes(University of Dundee), Peter Ettmayer(Boehringer Ingelheim (Austria)), Mark Pearson(Boehringer Ingelheim (Austria)), Darryl B. McConnell(Boehringer Ingelheim (Austria)), Alessio Ciulli(University of Dundee)

Nature Chemical Biology

June 9, 2019

10.1038/s41589-019-0294-6

Cited by 572Open Access

Full Text

Abstract

Related Papers

No related papers found

Powered by citation graph analysis