Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection

Seyedeh M. Zekavat; Shu‐Hong Lin; Alexander G. Bick; Aoxing Liu; Kaavya Paruchuri; Chen Wang; Md Mesbah Uddin; Yixuan Ye; Zhaolong Yu; Xiaoxi Liu; Yoichiro Kamatani; Romit Bhattacharya; James P. Pirruccello; Akhil Pampana; Po‐Ru Loh; Puja Kohli; Steven A. McCarroll; Krzysztof Kiryluk; Benjamin M. Neale; Iuliana Ionita‐Laza; Eric A. Engels; Derek W. Brown; Jordan W. Smoller; Robert C. Green; Elizabeth W. Karlson; Matthew S. Lebo; Patrick T. Ellinor; Scott T. Weiss; Mark J. Daly; The Biobank Japan Project; Satoshi Koyama; Kaoru Ito; Yukihide Momozawa; Koichi Matsuda; Yuji Yamanashi; Yoichi Furukawa; Takayuki Morisaki; Yoshinori Murakami; Kaori Muto; Akiko Nagai; Wataru Obara; Ken Yamaji; Kazuhisa Takahashi; Satoshi Asai; Yasuo Takahashi; Takao Suzuki; Nobuaki Sinozaki; Hiroki Yamaguchi; Shiro Minami; Shigeo Murayama; Kozo Yoshimori; Satoshi Nagayama; Daisuke Obata; Masahiko Higashiyama; Akihide Masumoto; Yukihiro Koretsune; Aarno Palotie; Adam Ziemann; Adele A. Mitchell; Adriana Huertas‐Vázquez; Aino Salminen; Airi Jussila; Aki S. Havulinna; Alex Mackay; Ali Abbasi; Amanda Elliott; Amy L. Cole; Anastasia Shcherban; Anders Mälarstig; Andrea Ganna; Andrey Loboda; Anna Podgornaia; Anne Lehtonen; Anne Pitkäranta; Anne M. Remes; Annika Auranen; Antti Hakanen; Antti Palomäki; Anu Jalanko; Anu Loukola; Aparna Chhibber; Apinya Lertratanakul; Arto Lehistö; Arto Mannermaa; Åsa K. Hedman; Audrey Y. Chu; Aviv Madar; Awaisa Ghazal; Benjamin Challis; Benjamin B. Sun; Beryl B. Cummings; Bridget Riley‐Gillis; Caroline S. Fox; Chia‐Yen Chen; Clarence Wang; Clément Chatelain; Daniel Gordin; Danjuma Quarless; Danny Oh; David F. Choy; David A. Close; David Pulford; David Rice; Dawn Waterworth; Deepak K. Rajpal; Denis Baird; Dhanaprakash Jambulingam; Diana Chang; Diptee Kulkarni; Dirk S. Paul; Dongyu Liu; Edmond Teng; Eero Punkka; Eeva Ekholm; Eeva Kangasniemi; Eija K. Laakkonen; Eleonor Wigmore; Elina Järvensivu; Elina Kilpeläinen; Elisabeth Widén; Ellen Tsai; Elmutaz Shaikho Elhaj Mohammed; Erich C. Strauss; Erika Kvikstad; Esa Pitkänen; Essi Kaiharju; Ethan Xu; Fanli Xu; Fedik Rahimov; Felix Vaura; Franck Augé; Georg Brein; Glenda Lassi; Graham Heap; Hannele Laivuori; Hannele Mattsson; Hannele Uusitalo‐Järvinen; Hannu Kankaanranta; Hannu Uusitalo; Hao Chen; Harri Siirtola; Heikki Joensuu; Heiko Runz; Heli Lehtonen; Henrike Heyne; Hilkka Soininen; Howard J. Jacob; Hubert Chen; Huei-Yi Shen; Huilei Xu; Iida Vähätalo; Ilkka Kalliala; Ioanna Tachmazidou; Jaakko Kaprio; Jaakko Parkkinen; Jaison Jacob; Janet Kumar; Janet van Adelsberg; Jari A. Laukkanen; Jarmo Ritari; Javier Gracia‐Tabuenca; Jeffrey F. Waring; Jennifer L. Schutzman; Jimmy Liu; Jiwoo Lee; Joanna Betts; Joel Rämö; Johanna Huhtakangas; Johanna Mäkelä; Johanna Mattson; Johanna Schleutker; Johannes Kettunen; John D. Eicher; Jonas Zierer; Jonathan Chung; Joni A. Turunen; Jorge Esparza Gordillo; Joseph Maranville; Juha Karjalainen; Juha Mehtonen; Juha O. Rinne; Juha Sinisalo; Juhani Junttila; Jukka Koskela; Jukka Partanen; Jukka Peltola; Julie Hunkapiller; Jussi Pihlajamäki; J S H Wade; Juulia Partanen; Kaarin Mäkikallio; Kai Kaarniranta; Kaisa Tasanen; Kaj Metsärinne; Kalle Pärn; Karen S. King; Kari K. Eklund; Kari Linden; Kari Nieminen; Katariina Hannula‐Jouppi; Katherine M. Call; K. Klinger; Kati Donner; Kati Hyvärinen; Kati Kristiansson; Katja Kivinen; Katri Kaukinen; Katri Pylkäs; Katrina de Lange; Keith Usiskin; Kimmo Palin; Kirill Shkura; Kirsi Auro; Kirsi Kalpala; Kirsi Sipilä; Klaus Elenius; Kristin Tsuo; L. Elisa Lahtela; Laura Addis; Laura Huilaja; Laura Kotaniemi‐Talonen; Laura Mustaniemi; Laura Pirilä; Laure Morin‐Papunen; Lauri A. Aaltonen; Leena Koulu; Liisa Suominen; Lila Kallio; Linda McCarthy; Liu Aoxing; Lotta Männikkö; Ma’en Obeidat; Manuel A. Rivas; Marco Hautalahti; Margit Pelkonen; Mari Kaunisto; Mari Niemi; Maria Siponen; Marika Crohns; Marita Kalaoja; Marja Luodonpää; Marja Vääräsmäki; Marja‐Riitta Taskinen; Marjo Tuppurainen; Mark J. Daly; Mark I. McCarthy; Markku Laakso; Markku Laukkanen; Markku Voutilainen; Markus Juonala; Markus Perola; Marla Hochfeld; Martti Färkkilâ; Mary Pat Reeve; Masahiro Kanai; Matt Brauer; Matthias Gossel; Matti Peura; Meg Ehm; Melissa Miller; Mengzhen Liu; Mervi Aavikko; Miika Koskinen; Mika Helminen; Mika Kähönen; Mikko Arvas; Mikko Hiltunen; Mikko Kiviniemi; Minal Çalışkan; Minna K. Karjalainen; Minna Raivio; Mirkka Koivusalo; Mitja Kurki; Mutaamba Maasha; Nan Bing; Natalie Bowers; Neha Raghavan; Nicole Renaud; Niko Välimäki; Nina Hautala; Nina Mars; Nina Pitkänen; Nizar Smaoui; Oili Kaipiainen‐Seppänen; Olli Carpén; Oluwaseun Alexander Dada; Onuralp Söylemez; Oskari Heikinheimo; Outi Tuovila; Outi Uimari; Padhraig Gormley; Päivi Auvinen; Päivi Laiho; Päivi Mäntylä; Päivi Polo; Paola G. Bronson; Paula Kauppi; Peeter Karihtala; Pekka Nieminen; Pentti J. Tienari; Petri Virolainen; Pia Isomäki; Pietro Della Briotta Parolo; Pirkko J. Pussinen; Priit Palta; Raimo Pakkanen; Raisa Serpi; Rajashree Mishra; Reetta Hinttala; Reetta Kälviäinen; Regis Wong; Relja Popovic; Richard W. Siegel; Riitta Lahesmaa; Risto Kajanne; Robert Graham; Robert M. Plenge; Robert Yang; Roosa Kallionpää; Ruoyu Tian; Russell Miller; Sahar Esmaeeli; Saila Kauppila; Sally John; Sami Heikkinen; Sami Koskelainen; Samir Wadhawan; Sampsa Pikkarainen; Samuel Heron; Samuli Ripatti; Sanna Seitsonen; Sanni Lahdenperä; Sanni Ruotsalainen; Sarah A. Pendergrass; Sarah Smith; S. Vuoti; Shabbeer Hassan; Shameek Biswas; Shuang Luo; Sina Rüeger; Sini Lähteenmäki; Sirkku Peltonen; Sirpa Soini; Slavé Petrovski; Soumitra Ghosh; Stefan McDonough; Stephanie Loomis; Steven M. Greenberg; Susan Eaton; Susanna Lemmelä; Tai-he Xia; Tarja Laitinen; Taru Tukiainen; Teea Salmi; Teemu Niiranen; Teemu Paajanen; Teijo Kuopio; Terhi Kilpi; Terhi Ollila; Tero Hiekkalinna; Tero Jyrhämä; Terttu Harju; Tiina Luukkaala; Tiinamaija Tuomi; Timothy E.J. Behrens; Tim Lu; Timo Blomster; Timo P. Sipilä; Tom Southerington; Tomi P. Mäkelä; Tuomo Kiiskinen; Tuomo Mantere; Tuomo J Meretoja; Tushar Bhangale; Tuula Salo; Tuuli Sistonen; Ulla Palotie; Ulvi Kahraman Gürsoy; Urho M. Kujala; Valtteri Julkunen; Veikko Salomaa; Veli‐Matti Kosma; Venkat Subramaniam Rathinakannan; Venla Kurra; Vesa Aaltonen; Victor Neduva; Vincent Llorens; Vishal Sinha; Vuokko Anttonen; Wei Zhou; Wilco Fleuren; Xing Chen; Xinli Hu; Ying Wu; Yunfeng Huang; Chikashi Terao; Hongyu Zhao; Benjamin L. Ebert; Muredach P. Reilly; Andrea Ganna; Mitchell J. Machiela; Giulio Genovese; Pradeep Natarajan

doi:10.1038/s41591-021-01371-0

Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection

Seyedeh M. Zekavat(Broad Institute), Shu‐Hong Lin(National Cancer Institute), Alexander G. Bick(Broad Institute), Aoxing Liu(Institute for Molecular Medicine Finland), Kaavya Paruchuri(Broad Institute), Chen Wang(Columbia University), Md Mesbah Uddin(Broad Institute), Yixuan Ye(Yale University), Zhaolong Yu(Yale University), Xiaoxi Liu(RIKEN Center for Integrative Medical Sciences), Yoichiro Kamatani(RIKEN Center for Integrative Medical Sciences), Romit Bhattacharya(Massachusetts General Hospital), James P. Pirruccello(Broad Institute), Akhil Pampana(Broad Institute), Po‐Ru Loh(Broad Institute), Puja Kohli(Brigham and Women's Hospital), Steven A. McCarroll(Broad Institute), Krzysztof Kiryluk(Columbia University), Benjamin M. Neale(Broad Institute), Iuliana Ionita‐Laza(Columbia University), Eric A. Engels(National Cancer Institute), Derek W. Brown(National Cancer Institute), Jordan W. Smoller(Broad Institute), Robert C. Green(Broad Institute), Elizabeth W. Karlson(Brigham and Women's Hospital), Matthew S. Lebo(Brigham and Women's Hospital), Patrick T. Ellinor(Broad Institute), Scott T. Weiss(Brigham and Women's Hospital), Mark J. Daly(Institute for Molecular Medicine Finland), The Biobank Japan Project(RIKEN Center for Integrative Medical Sciences), Satoshi Koyama(RIKEN Center for Integrative Medical Sciences), Kaoru Ito(RIKEN Center for Integrative Medical Sciences), Yukihide Momozawa(RIKEN Center for Integrative Medical Sciences), Koichi Matsuda(The University of Tokyo), Yuji Yamanashi(The University of Tokyo), Yoichi Furukawa(University of Tokyo Hospital), Takayuki Morisaki(University of Tokyo Hospital), Yoshinori Murakami(The University of Tokyo), Kaori Muto(The University of Tokyo), Akiko Nagai(Iwate Medical University), Wataru Obara(Iwate Medical University), Ken Yamaji(Juntendo University), Kazuhisa Takahashi(Nihon University), Satoshi Asai(Nihon University), Yasuo Takahashi(Nihon University), Takao Suzuki(Fukuoka Tokushukai Hospital), Nobuaki Sinozaki(Fukuoka Tokushukai Hospital), Hiroki Yamaguchi(Nippon Medical School), Shiro Minami(Tokyo Metropolitan Geriatric Hospital), Shigeo Murayama(Japan Anti Tuberculosis Association), Kozo Yoshimori(Japan Anti Tuberculosis Association), Satoshi Nagayama(Shiga University of Medical Science), Daisuke Obata(Shiga University of Medical Science), Masahiko Higashiyama(Aso Iizuka Hospital), Akihide Masumoto(Osaka National Hospital), Yukihiro Koretsune(University of Helsinki), Aarno Palotie(University of Helsinki), Adam Ziemann(Biogen (United States)), Adele A. Mitchell(Merck & Co., Inc., Rahway, NJ, USA (United States)), Adriana Huertas‐Vázquez(Merck & Co., Inc., Rahway, NJ, USA (United States)), Aino Salminen(Pirkanmaa Hospital District), Airi Jussila(University of Helsinki), Aki S. Havulinna(AstraZeneca (United Kingdom)), Alex Mackay(AstraZeneca (United Kingdom)), Ali Abbasi(University of Helsinki), Amanda Elliott(Broad Institute), Amy L. Cole(Novartis (Switzerland)), Anastasia Shcherban(University of Helsinki), Anders Mälarstig(Broad Institute), Andrea Ganna(Broad Institute), Andrey Loboda(Merck & Co., Inc., Rahway, NJ, USA (United States)), Anna Podgornaia(Merck & Co., Inc., Rahway, NJ, USA (United States)), Anne Lehtonen(AbbVie (United States)), Anne Pitkäranta(Northern Ostrobothnia Hospital District), Anne M. Remes(Pirkanmaa Hospital District), Annika Auranen(University of Turku), Antti Hakanen(University of Turku), Antti Palomäki(University of Helsinki), Anu Jalanko(University of Helsinki), Anu Loukola(Merck & Co., Inc., Rahway, NJ, USA (United States)), Aparna Chhibber(Merck & Co., Inc., Rahway, NJ, USA (United States)), Apinya Lertratanakul(University of Helsinki), Arto Lehistö(University of Helsinki), Arto Mannermaa(University of Eastern Finland), Åsa K. Hedman(Pfizer (United States)), Audrey Y. Chu(Novartis (Switzerland)), Aviv Madar(Novartis (Switzerland)), Awaisa Ghazal(AstraZeneca (United Kingdom)), Benjamin Challis(AstraZeneca (United Kingdom)), Benjamin B. Sun(Biogen (United States)), Beryl B. Cummings(AbbVie (United States)), Bridget Riley‐Gillis(Merck & Co., Inc., Rahway, NJ, USA (United States)), Caroline S. Fox(Merck & Co., Inc., Rahway, NJ, USA (United States)), Chia‐Yen Chen(Biogen (United States)), Clarence Wang(Sanofi (France)), Clément Chatelain(Sanofi (France)), Daniel Gordin(AbbVie (United States)), Danjuma Quarless(AbbVie (United States)), Danny Oh, David F. Choy(AstraZeneca (United Kingdom)), David A. Close(AstraZeneca (United Kingdom)), David Pulford(GlaxoSmithKline (United Kingdom)), David Rice(Janssen (Belgium)), Dawn Waterworth(Janssen (Belgium)), Deepak K. Rajpal(Biogen (United States)), Denis Baird(Biogen (United States)), Dhanaprakash Jambulingam(University of Turku), Diana Chang(GlaxoSmithKline (United Kingdom)), Diptee Kulkarni(AstraZeneca (United Kingdom)), Dirk S. Paul(AstraZeneca (United Kingdom)), Dongyu Liu(Sanofi (France)), Edmond Teng(Hospital District of Helsinki and Uusimaa), Eero Punkka(Varsinais-Suomen Sairaanhoitopiiri), Eeva Ekholm(Tampere University), Eeva Kangasniemi(Tampere University), Eija K. Laakkonen(AstraZeneca (United Kingdom)), Eleonor Wigmore(AstraZeneca (United Kingdom)), Elina Järvensivu(University of Helsinki), Elina Kilpeläinen(University of Helsinki), Elisabeth Widén(Biogen (United States)), Ellen Tsai(Biogen (United States)), Elmutaz Shaikho Elhaj Mohammed, Erich C. Strauss, Erika Kvikstad(University of Helsinki), Esa Pitkänen(University of Helsinki), Essi Kaiharju(Sanofi (France)), Ethan Xu(GlaxoSmithKline (United Kingdom)), Fanli Xu(GlaxoSmithKline (United Kingdom)), Fedik Rahimov(AbbVie (United States)), Felix Vaura(Sanofi (France)), Franck Augé(University of Helsinki), Georg Brein(AstraZeneca (United Kingdom)), Glenda Lassi(AstraZeneca (United Kingdom)), Graham Heap(University of Helsinki), Hannele Laivuori(University of Helsinki), Hannele Mattsson(Finnish Institute for Health and Welfare), Hannele Uusitalo‐Järvinen(Pirkanmaa Hospital District), Hannu Kankaanranta(Pirkanmaa Hospital District), Hannu Uusitalo(Pirkanmaa Hospital District), Hao Chen(Tampere University), Harri Siirtola(Tampere University), Heikki Joensuu(Biogen (United States)), Heiko Runz(Biogen (United States)), Heli Lehtonen(University of Helsinki), Henrike Heyne(University of Helsinki), Hilkka Soininen(AbbVie (United States)), Howard J. Jacob(AbbVie (United States)), Hubert Chen(University of Helsinki), Huei-Yi Shen(Novartis (Switzerland)), Huilei Xu(Novartis (Switzerland)), Iida Vähätalo(Tampere University), Ilkka Kalliala(AstraZeneca (United Kingdom)), Ioanna Tachmazidou(AstraZeneca (United Kingdom)), Jaakko Kaprio(University of Helsinki), Jaakko Parkkinen(Novartis (Switzerland)), Jaison Jacob(Novartis (Switzerland)), Janet Kumar(GlaxoSmithKline (United Kingdom)), Janet van Adelsberg(Bristol-Myers Squibb (United States)), Jari A. Laukkanen(Finnish Red Cross), Jarmo Ritari(Tampere University), Javier Gracia‐Tabuenca(Tampere University), Jeffrey F. Waring(AbbVie (United States)), Jennifer L. Schutzman(GlaxoSmithKline (United Kingdom)), Jimmy Liu(Broad Institute), Jiwoo Lee(Broad Institute), Joanna Betts(University of Helsinki), Joel Rämö(University of Helsinki), Johanna Huhtakangas(Tampere University), Johanna Mäkelä(Tampere University), Johanna Mattson(University of Turku), Johanna Schleutker(University of Turku), Johannes Kettunen(GlaxoSmithKline (United Kingdom)), John D. Eicher(Novartis (Switzerland)), Jonas Zierer(Novartis (Switzerland)), Jonathan Chung(Novartis (Switzerland)), Joni A. Turunen(GlaxoSmithKline (United Kingdom)), Jorge Esparza Gordillo(GlaxoSmithKline (United Kingdom)), Joseph Maranville(Broad Institute), Juha Karjalainen(Broad Institute), Juha Mehtonen(University of Helsinki), Juha O. Rinne(Varsinais-Suomen Sairaanhoitopiiri), Juha Sinisalo(Borealis (Finland)), Juhani Junttila(Borealis (Finland)), Jukka Koskela(Finnish Red Cross), Jukka Partanen(University of Helsinki), Jukka Peltola(Pirkanmaa Hospital District), Julie Hunkapiller(Tampere University), Jussi Pihlajamäki(Tampere University), J S H Wade(University of Helsinki), Juulia Partanen(University of Helsinki), Kaarin Mäkikallio(Varsinais-Suomen Sairaanhoitopiiri), Kai Kaarniranta(Northern Ostrobothnia Hospital District), Kaisa Tasanen(Varsinais-Suomen Sairaanhoitopiiri), Kaj Metsärinne(University of Helsinki), Kalle Pärn(University of Helsinki), Karen S. King(GlaxoSmithKline (United Kingdom)), Kari K. Eklund(Pfizer (United States)), Kari Linden(Pfizer (United States)), Kari Nieminen(Pirkanmaa Hospital District), Katariina Hannula‐Jouppi(Sanofi (France)), Katherine M. Call(Sanofi (France)), K. Klinger(University of Helsinki), Kati Donner(University of Helsinki), Kati Hyvärinen(Finnish Red Cross), Kati Kristiansson(University of Helsinki), Katja Kivinen(University of Helsinki), Katri Kaukinen(Pirkanmaa Hospital District), Katri Pylkäs(Novartis (Switzerland)), Katrina de Lange(Novartis (Switzerland)), Keith Usiskin(University of Helsinki), Kimmo Palin(Merck & Co., Inc., Rahway, NJ, USA (United States)), Kirill Shkura(Merck & Co., Inc., Rahway, NJ, USA (United States)), Kirsi Auro(Pfizer (United States)), Kirsi Kalpala(Pfizer (United States)), Kirsi Sipilä(Varsinais-Suomen Sairaanhoitopiiri), Klaus Elenius(Broad Institute), Kristin Tsuo(Broad Institute), L. Elisa Lahtela(University of Helsinki), Laura Addis(GlaxoSmithKline (United Kingdom)), Laura Huilaja(Pirkanmaa Hospital District), Laura Kotaniemi‐Talonen(Pirkanmaa Hospital District), Laura Mustaniemi(Varsinais-Suomen Sairaanhoitopiiri), Laura Pirilä(Varsinais-Suomen Sairaanhoitopiiri), Laure Morin‐Papunen(Northern Ostrobothnia Hospital District), Lauri A. Aaltonen(Varsinais-Suomen Sairaanhoitopiiri), Leena Koulu(Varsinais-Suomen Sairaanhoitopiiri), Liisa Suominen(University of Turku), Lila Kallio(University of Turku), Linda McCarthy(University of Helsinki), Liu Aoxing(University of Helsinki), Lotta Männikkö(Novartis (Switzerland)), Ma’en Obeidat(Novartis (Switzerland)), Manuel A. Rivas(Stanford University), Marco Hautalahti, Margit Pelkonen(University of Helsinki), Mari Kaunisto(University of Helsinki), Mari Niemi(University of Helsinki), Maria Siponen(Sanofi (France)), Marika Crohns(Sanofi (France)), Marita Kalaoja(Northern Ostrobothnia Hospital District), Marja Luodonpää(Northern Ostrobothnia Hospital District), Marja Vääräsmäki(Northern Ostrobothnia Hospital District), Marja‐Riitta Taskinen(Hospital District of Helsinki and Uusimaa), Marjo Tuppurainen(University of Helsinki), Mark J. Daly(Institute for Molecular Medicine Finland), Mark I. McCarthy, Markku Laakso(Finnish Institute for Health and Welfare), Markku Laukkanen(Finnish Institute for Health and Welfare), Markku Voutilainen(Varsinais-Suomen Sairaanhoitopiiri), Markus Juonala(Finnish Institute for Health and Welfare), Markus Perola(Finnish Institute for Health and Welfare), Marla Hochfeld(Bristol-Myers Squibb (United States)), Martti Färkkilâ(University of Helsinki), Mary Pat Reeve(University of Helsinki), Masahiro Kanai(Maze (United States)), Matt Brauer(Sanofi (France)), Matthias Gossel(University of Helsinki), Matti Peura(University of Helsinki), Meg Ehm(Pfizer (United States)), Melissa Miller(Pfizer (United States)), Mengzhen Liu(University of Helsinki), Mervi Aavikko(University of Helsinki), Miika Koskinen(Tampere University), Mika Helminen(Tampere University), Mika Kähönen(Finnish Red Cross), Mikko Arvas(Finnish Red Cross), Mikko Hiltunen, Mikko Kiviniemi(Bristol-Myers Squibb (United States)), Minal Çalışkan(Bristol-Myers Squibb (United States)), Minna K. Karjalainen(Hospital District of Helsinki and Uusimaa), Minna Raivio(Hospital District of Helsinki and Uusimaa), Mirkka Koivusalo(Broad Institute), Mitja Kurki(Broad Institute), Mutaamba Maasha(Pfizer (United States)), Nan Bing(Pfizer (United States)), Natalie Bowers(Merck & Co., Inc., Rahway, NJ, USA (United States)), Neha Raghavan(Novartis (Switzerland)), Nicole Renaud(Novartis (Switzerland)), Niko Välimäki(University of Helsinki), Nina Hautala(University of Helsinki), Nina Mars(University of Helsinki), Nina Pitkänen(University of Turku), Nizar Smaoui(AbbVie (United States)), Oili Kaipiainen‐Seppänen(Hospital District of Helsinki and Uusimaa), Olli Carpén(University of Helsinki), Oluwaseun Alexander Dada(Merck & Co., Inc., Rahway, NJ, USA (United States)), Onuralp Söylemez(Merck & Co., Inc., Rahway, NJ, USA (United States)), Oskari Heikinheimo(Hospital District of Helsinki and Uusimaa), Outi Tuovila(Northern Ostrobothnia Hospital District), Outi Uimari(GlaxoSmithKline (United Kingdom)), Padhraig Gormley(GlaxoSmithKline (United Kingdom)), Päivi Auvinen(Finnish Institute for Health and Welfare), Päivi Laiho(Finnish Institute for Health and Welfare), Päivi Mäntylä(Varsinais-Suomen Sairaanhoitopiiri), Päivi Polo(Biogen (United States)), Paola G. Bronson(Biogen (United States)), Paula Kauppi(Northern Ostrobothnia Hospital District), Peeter Karihtala(Northern Ostrobothnia Hospital District), Pekka Nieminen(Hospital District of Helsinki and Uusimaa), Pentti J. Tienari(University of Turku), Petri Virolainen(University of Turku), Pia Isomäki(University of Helsinki), Pietro Della Briotta Parolo(University of Helsinki), Pirkko J. Pussinen(University of Helsinki), Priit Palta(University of Helsinki), Raimo Pakkanen(Borealis (Finland)), Raisa Serpi(GlaxoSmithKline (United Kingdom)), Rajashree Mishra(GlaxoSmithKline (United Kingdom)), Reetta Hinttala(Borealis (Finland)), Reetta Kälviäinen(Finnish Institute for Health and Welfare), Regis Wong(AbbVie (United States)), Relja Popovic(Novartis (Switzerland)), Richard W. Siegel(Novartis (Switzerland)), Riitta Lahesmaa(University of Helsinki), Risto Kajanne(University of Helsinki), Robert Graham(Bristol-Myers Squibb (United States)), Robert M. Plenge(Janssen (Belgium)), Robert Yang(Janssen (Belgium)), Roosa Kallionpää(Biogen (United States)), Ruoyu Tian(Biogen (United States)), Russell Miller(Pfizer (United States)), Sahar Esmaeeli(AbbVie (United States)), Saila Kauppila(Biogen (United States)), Sally John(Biogen (United States)), Sami Heikkinen(University of Eastern Finland), Sami Koskelainen(Finnish Institute for Health and Welfare), Samir Wadhawan(Bristol-Myers Squibb (United States)), Sampsa Pikkarainen(University of Turku), Samuel Heron(University of Helsinki), Samuli Ripatti(University of Helsinki), Sanna Seitsonen(Biogen (United States)), Sanni Lahdenperä(Biogen (United States)), Sanni Ruotsalainen(University of Helsinki), Sarah A. Pendergrass, Sarah Smith(Sanofi (France)), S. Vuoti(University of Helsinki), Shabbeer Hassan(University of Helsinki), Shameek Biswas(University of Helsinki), Shuang Luo(University of Helsinki), Sina Rüeger(University of Helsinki), Sini Lähteenmäki(Finnish Institute for Health and Welfare), Sirkku Peltonen(Finnish Institute for Health and Welfare), Sirpa Soini(AstraZeneca (United Kingdom)), Slavé Petrovski(AstraZeneca (United Kingdom)), Soumitra Ghosh(Pfizer (United States)), Stefan McDonough(Biogen (United States)), Stephanie Loomis(Biogen (United States)), Steven M. Greenberg(Biogen (United States)), Susan Eaton(Biogen (United States)), Susanna Lemmelä(University of Helsinki), Tai-he Xia(Tampere University), Tarja Laitinen(University of Helsinki), Taru Tukiainen(University of Helsinki), Teea Salmi(Finnish Institute for Health and Welfare), Teemu Niiranen(Finnish Institute for Health and Welfare), Teemu Paajanen(Finnish Institute for Health and Welfare), Teijo Kuopio(Finnish Institute for Health and Welfare), Terhi Kilpi(Finnish Institute for Health and Welfare), Terhi Ollila(Finnish Institute for Health and Welfare), Tero Hiekkalinna(University of Helsinki), Tero Jyrhämä(University of Helsinki), Terttu Harju(Tampere University), Tiina Luukkaala(Tampere University), Tiinamaija Tuomi(Maze (United States)), Timothy E.J. Behrens(Maze (United States)), Tim Lu(Northern Ostrobothnia Hospital District), Timo Blomster(University of Helsinki), Timo P. Sipilä(University of Helsinki), Tom Southerington(University of Helsinki), Tomi P. Mäkelä(University of Helsinki), Tuomo Kiiskinen(University of Helsinki), Tuomo Mantere(Borealis (Finland)), Tuomo J Meretoja(Hospital District of Helsinki and Uusimaa), Tushar Bhangale(Hospital District of Helsinki and Uusimaa), Tuula Salo(Finnish Institute for Health and Welfare), Tuuli Sistonen(Finnish Institute for Health and Welfare), Ulla Palotie(Varsinais-Suomen Sairaanhoitopiiri), Ulvi Kahraman Gürsoy(Varsinais-Suomen Sairaanhoitopiiri), Urho M. Kujala(Central Finland Health Care District), Valtteri Julkunen(Finnish Institute for Health and Welfare), Veikko Salomaa(University of Eastern Finland), Veli‐Matti Kosma(University of Turku), Venkat Subramaniam Rathinakannan(University of Turku), Venla Kurra(Pirkanmaa Hospital District), Vesa Aaltonen(Merck & Co., Inc., Rahway, NJ, USA (United States)), Victor Neduva(Merck & Co., Inc., Rahway, NJ, USA (United States)), Vincent Llorens(University of Helsinki), Vishal Sinha(University of Helsinki), Vuokko Anttonen(Northern Ostrobothnia Hospital District), Wei Zhou(Janssen (Belgium)), Wilco Fleuren(Janssen (Belgium)), Xing Chen(Pfizer (United States)), Xinli Hu(Pfizer (United States)), Ying Wu(Biogen (United States)), Yunfeng Huang(Biogen (United States)), Chikashi Terao(University of Shizuoka), Hongyu Zhao(Howard Hughes Medical Institute), Benjamin L. Ebert(Broad Institute), Muredach P. Reilly(Broad Institute), Andrea Ganna(Broad Institute), Mitchell J. Machiela(Broad Institute), Giulio Genovese(Broad Institute), Pradeep Natarajan(Broad Institute)

Nature Medicine

June 1, 2021

10.1038/s41591-021-01371-0

Cited by 190Open Access

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