Front Cover: A Single Second Shell Amino Acid Determines Affinity and Kinetics of Linagliptin Binding to Type 4 Dipeptidyl Peptidase and Fibroblast Activation Protein (ChemMedChem 4/2021)

Gisela Schnapp(Boehringer Ingelheim (Germany)), Herbert Nar(Boehringer Ingelheim (Germany)), Remko A. Bakker(Boehringer Ingelheim (Germany)), Thomas Klein(Central Institute for Art History), Yvette Hoevels(Boehringer Ingelheim (Germany)), Patrick Schreiner(ProterixBio (United States))
ChemMedChem
February 17, 2021
10.1002/cmdc.202100054
Cited by 0

Related Papers

A specific antidote for dabigatran: functional and structural characterization
|Blood|2013|562
Crystal structure analysis of oxidized Pseudomonas aeruginosa azurin at pH 5·5 and pH 9·0
|Journal of Molecular Biology|1991|487
Structure-Based Design of Novel Potent Nonpeptide Thrombin Inhibitors
|Journal of Medicinal Chemistry|2002|454
Biophysics in drug discovery: impact, challenges and opportunities
|Nature Reviews Drug Discovery|2016|383
8-(3-(<i>R</i>)-Aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a Highly Potent, Selective, Long-Acting, and Orally Bioavailable DPP-4 Inhibitor for the Treatment of Type 2 Diabetes
|Journal of Medicinal Chemistry|2007|285