Tumor microenvironment remodeling and tumor therapy based on M2-like tumor associated macrophage-targeting nano-complexes
Shulan Han(Institute of Process Engineering), Wenjie Wang, Shengfang Wang, Tingyuan Yang(Institute of Process Engineering), Guifeng Zhang(Institute of Process Engineering), Di Wang(Beijing Institute of Petrochemical Technology), Rui-Jun Ju(Beijing Institute of Petrochemical Technology), Yu Lu, Huimei Wang, Lianyan Wang(Institute of Process Engineering)
Cited by 268Open Access
Abstract
The nano-complexes facilitated baicalin, antigen, and immunostimulant delivery to M2-like TAMs, which polarized and reversed the M2-like TAM phenotype and remodeled the tumor microenvironment to allow killing of tumor cells.
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