Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 By Disrupting The Spike-ACE2 interaction

Scott E. Guimond(Keele University), Jeremy E. Turnbull(University of Copenhagen), C. Mirella Spalluto(University of Southampton), Alexander A. Khromykh(The University of Queensland), Julia A. Tree(UK Health Security Agency), Naomi S. Coombes(Public Health England), Marcelo A. Lima(Keele University), Alberto A. Amarilla(Commonwealth Scientific and Industrial Research Organisation), Julian D. J. Sng(The University of Queensland), Daniel Watterson(The University of Queensland), James P. Stewart(University of Liverpool), Edward Trybala(University of Gothenburg), Zhang Yang(Baylor College of Medicine), María Victoria Humbert(University of Southampton), Courtney J. Mycroft‐West(Rosalind Franklin Institute), Edwin A. Yates(University of Birmingham), Vito Ferro(The University of Queensland), Andreas Suhrbier(The University of Queensland), Tomas Bergström(Sahlgrenska University Hospital), Ieva Bagdonaite(University of Copenhagen), Keith Dredge, Richard Karlsson(University of Copenhagen), Yin Xiang Setoh(Takeda (Singapore)), Michael J. Elmore(Defence Science and Technology Laboratory), Edward Hammond(American Cancer Society), Tom Wilkinson(University Hospital Southampton NHS Foundation Trust), Miles W. Carroll(Institute of Human Genetics), Paul R. Young(Kent State University), Joanna Said(University of Gothenburg), Neha S. Gandhi(Queensland University of Technology), Kristina Nystrôm(University of Gothenburg), Yen‐Hsi Chen(University of Copenhagen), Naphak Modhiran(The University of Queensland), Rebecca L. Miller(University of Copenhagen), Thuy T. Le(The University of Melbourne), Mohit Chhabra(The University of Queensland), Karen R. Buttigieg(Bradford Teaching Hospitals NHS Foundation Trust), Mark A. Skidmore(Keele University)
bioRxiv (Cold Spring Harbor Laboratory)
June 24, 2020
Cited by 12


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