Comparison of nonhuman primates identified the suitable model for COVID-19

Shuaiyao Lu(Chinese Academy of Medical Sciences & Peking Union Medical College), Yuan Zhao(Chinese Academy of Medical Sciences & Peking Union Medical College), Wenhai Yu(Chinese Academy of Medical Sciences & Peking Union Medical College), Yun Yang(Chinese Academy of Medical Sciences & Peking Union Medical College), Jiahong Gao(Chinese Academy of Medical Sciences & Peking Union Medical College), Junbin Wang(Chinese Academy of Medical Sciences & Peking Union Medical College), Dexuan Kuang(Chinese Academy of Medical Sciences & Peking Union Medical College), Mengli Yang(Chinese Academy of Medical Sciences & Peking Union Medical College), Jing Yang(Chinese Academy of Medical Sciences & Peking Union Medical College), Chunxia Ma(Chinese Academy of Medical Sciences & Peking Union Medical College), Jingwen Xu(Chinese Academy of Medical Sciences & Peking Union Medical College), Xingli Qian(Chinese Academy of Medical Sciences & Peking Union Medical College), Haiyan Li(Chinese Academy of Medical Sciences & Peking Union Medical College), Siwen Zhao(Chinese Academy of Medical Sciences & Peking Union Medical College), Jingmei Li(Chinese Academy of Medical Sciences & Peking Union Medical College), Haixuan Wang(Chinese Academy of Medical Sciences & Peking Union Medical College), Haiting Long(Chinese Academy of Medical Sciences & Peking Union Medical College), Jingxian Zhou(Chinese Academy of Medical Sciences & Peking Union Medical College), Fangyu Luo(Chinese Academy of Medical Sciences & Peking Union Medical College), Kaiyun Ding(Chinese Academy of Medical Sciences & Peking Union Medical College), Daoju Wu(Chinese Academy of Medical Sciences & Peking Union Medical College), Yong Zhang(Chinese Academy of Medical Sciences & Peking Union Medical College), Yinliang Dong(Chinese Academy of Medical Sciences & Peking Union Medical College), Yuqin Liu(Chinese Academy of Medical Sciences & Peking Union Medical College), Yinqiu Zheng(Chinese Academy of Medical Sciences & Peking Union Medical College), Xiaochen Lin(Chinese Academy of Medical Sciences & Peking Union Medical College), Jiao Li(Chinese Academy of Medical Sciences & Peking Union Medical College), Huanying Zheng(Guangdong Provincial Center for Disease Control and Prevention), Qing Dai(Chinese Academy of Medical Sciences & Peking Union Medical College), Qiangming Sun(Chinese Academy of Medical Sciences & Peking Union Medical College), Yunzhang Hu(Chinese Academy of Medical Sciences & Peking Union Medical College), Changwen Ke(Guangdong Provincial Center for Disease Control and Prevention), Hongqi Liu(Chinese Academy of Medical Sciences & Peking Union Medical College), Xiaozhong Peng(Chinese Academy of Medical Sciences & Peking Union Medical College)
Signal Transduction and Targeted Therapy
August 19, 2020
10.1038/s41392-020-00269-6
Cited by 237Open Access
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Abstract

Identification of a suitable nonhuman primate (NHP) model of COVID-19 remains challenging. Here, we characterized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in three NHP species: Old World monkeys Macaca mulatta (M. mulatta) and Macaca fascicularis (M. fascicularis) and New World monkey Callithrix jacchus (C. jacchus). Infected M. mulatta and M. fascicularis showed abnormal chest radiographs, an increased body temperature and a decreased body weight. Viral genomes were detected in swab and blood samples from all animals. Viral load was detected in the pulmonary tissues of M. mulatta and M. fascicularis but not C. jacchus. Furthermore, among the three animal species, M. mulatta showed the strongest response to SARS-CoV-2, including increased inflammatory cytokine expression and pathological changes in the pulmonary tissues. Collectively, these data revealed the different susceptibilities of Old World and New World monkeys to SARS-CoV-2 and identified M. mulatta as the most suitable for modeling COVID-19.

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