IRF2 transcriptionally induces <i>GSDMD</i> expression for pyroptosis
Nobuhiko Kayagaki(Department of Physiological Sciences), Bettina L. Lee(Department of Physiological Sciences), Irma B. Stowe(Department of Physiological Sciences), Opher S. Kornfeld(Department of Physiological Sciences), Karen O’Rourke(Department of Physiological Sciences), Kathleen M. Mirrashidi(Department of Physiological Sciences), Benjamin Haley, Colin Watanabe, Merone Roose‐Girma, Zora Modrušan, Sarah Kummerfeld, Rohit Reja, Yafei Zhang(Australian National University), Vicky Cho(Australian National University), T. Daniel Andrews(Australian National University), Lucy X. Morris(Australian National University), Christopher C. Goodnow(Garvan Institute of Medical Research), Edward M. Bertram(Australian National University), Vishva M. Dixit(Department of Physiological Sciences)
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Abstract
transcription for the execution of pyroptosis. Disruption of this single IRF2-binding site abolished signaling by both the canonical and noncanonical inflammasomes. Together, our data illuminate a key transcriptional mechanism for expression of the gene encoding GSDMD, a critical mediator of inflammatory pathologies.
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