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Karen O’Rourke

Fondation pour la Recherche Stratégique

Publishes on Cell death mechanisms and regulation, Ubiquitin and proteasome pathways, Angiogenesis and VEGF in Cancer. 56 papers and 29.2k citations.

56Publications

29.2kTotal Citations

Cell death mechanisms and regulation Ubiquitin and proteasome pathways Angiogenesis and VEGF in Cancer Protease and Inhibitor Mechanisms NF-κB Signaling Pathways

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Top publicationsby citations

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

Nobuhiko Kayagaki, Irma B. Stowe, Bettina L. Lee et al.|Nature|2015

Cited by 3.6k

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

Marta Muzio, Arul M. Chinnaiyan, Frank Kischkel et al.|Cell|1996

Cited by 3.1kOpen Access

Cryopyrin activates the inflammasome in response to toxins and ATP

Sanjeev Mariathasan, David S. Weiss, Kim Newton et al.|Nature|2006

Cited by 3kOpen Access

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

Arul M. Chinnaiyan, Karen O’Rourke, Muneesh Tewari et al.|Cell|1995

Cited by 2.4kOpen Access

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

Muneesh Tewari, Long T. Quan, Karen O’Rourke et al.|Cell|1995

Cited by 2.4kOpen Access