Conjugation of hydrophobic moieties enhances potency of antisense oligonucleotides in the muscle of rodents and non-human primates
Michael E. Østergaard(Ionis Pharmaceuticals (United States)), Punit P. Seth(Ionis Pharmaceuticals (United States)), Eric E. Swayze(Ionis Pharmaceuticals (United States)), Hans Gaus(Ionis Pharmaceuticals (United States)), Michael Tanowitz(Ionis Pharmaceuticals (United States)), Michaela Jackson(Ionis Pharmaceuticals (United States)), Adam E. Mullick(Ionis Pharmaceuticals (United States)), Frank Rigo(Ionis Pharmaceuticals (United States)), Audrey Low(Ionis Pharmaceuticals (United States)), Sue Murray(Ionis Pharmaceuticals (United States)), Alfred E. Chappell(Ionis Pharmaceuticals (United States)), Jinghua Yu(Albert Einstein College of Medicine), Rick Carty(Ionis Pharmaceuticals (United States)), Linda Fradkin(Ionis Pharmaceuticals (United States)), C. Frank Bennett(Pennsylvania State University), Thazha P. Prakash(Ionis Pharmaceuticals (United States)), Tae‐Won Kim(Chungnam National University), Amy Dan(Ionis Pharmaceuticals (United States)), Richard Lee(Ionis Pharmaceuticals (United States)), Rachel Q Peralta(Ionis Pharmaceuticals (United States)), Patrick N. Anderson(Ionis Pharmaceuticals (United States)), Garth A. Kinberger(Ionis Pharmaceuticals (United States))
Cited by 98
Related Papers
miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting
|Cell Metabolism|2006|2.1k
Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary<i>N</i>-acetyl galactosamine improves potency 10-fold in mice
|Nucleic Acids Research|2014|594
Regulation of the p85/p110 Phosphatidylinositol 3′-Kinase: Stabilization and Inhibition of the p110α Catalytic Subunit by the p85 Regulatory Subunit
|Molecular and Cellular Biology|1998|524
Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals
|Nucleic Acids Research|2006|461