Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria”
Chris H. Polman(Amsterdam UMC Location Vrije Universiteit Amsterdam), Stephen C. Reingold(National Multiple Sclerosis Society), Gilles Edan(Centre Hospitalier Universitaire de Rennes), Massimo Filippi(San Raffaele University of Rome), Hans‐Peter Hartung(Heinrich Heine University Düsseldorf), Ludwig Kappos(University Hospital of Basel), Fred Lublin(Icahn School of Medicine at Mount Sinai), Luanne M. Metz(Foothills Medical Centre), Henry F. McFarland(National Institute of Neurological Disorders and Stroke), Paul O’Connor(St. Michael's Hospital), Magnhild Sandberg‐Wollheim, Alan J. Thompson, Brian G. Weinshenker(Mayo Clinic), Jerry S. Wolinsky(The University of Texas Health Science Center at Houston)
Cited by 4,986Open Access
Abstract
New diagnostic criteria for multiple sclerosis integrating magnetic resonance image assessment with clinical and other paraclinical methods were introduced in 2001. The "McDonald Criteria" have been extensively assessed and used since 2001. New evidence and consensus now strengthen the role of these criteria in the multiple sclerosis diagnostic workup to demonstrate dissemination of lesions in time, to clarify the use of spinal cord lesions, and to simplify diagnosis of primary progressive disease. The 2005 Revisions to the McDonald Diagnostic Criteria for MS should simplify and speed diagnosis, whereas maintaining adequate sensitivity and specificity.
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