GPR40 modulates epileptic seizure and NMDA receptor function
Yong Yang(Qingdao University), Xin Tian(The Affiliated Yongchuan Hospital of Chongqing Medical University), Demei Xu(The Affiliated Yongchuan Hospital of Chongqing Medical University), Fangshuo Zheng(The Affiliated Yongchuan Hospital of Chongqing Medical University), Xi Lu(The Affiliated Yongchuan Hospital of Chongqing Medical University), Yanke Zhang(The Affiliated Yongchuan Hospital of Chongqing Medical University), Yuanlin Ma(The Affiliated Yongchuan Hospital of Chongqing Medical University), Yun Li(The Affiliated Yongchuan Hospital of Chongqing Medical University), Xin Xu(The Affiliated Yongchuan Hospital of Chongqing Medical University), Binglin Zhu(The Affiliated Yongchuan Hospital of Chongqing Medical University), Xuefeng Wang(Chinese Institute for Brain Research)
Cited by 65Open Access
Abstract
-methyl-d-aspartate (NMDA) receptor-mediated synaptic transmission. Moreover, GPR40 regulated NR2A and NR2B expression on the surface of neurons. In addition, endocytosis of NMDA receptors and binding of GPR40 with NR2A and NR2B can be regulated by GPR40. Together, our findings indicate that GPR40 modulates epileptic seizures, providing a novel antiepileptic target.
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