Lipophilic Efficiency as an Important Metric in Drug Design

Ted W. Johnson(WorldFish), Martin P. Edwards(Pfizer (United States)), Rebecca A. Gallego(Pfizer (United States))

Journal of Medicinal Chemistry

March 28, 2018

10.1021/acs.jmedchem.8b00077

Cited by 340

Related Papers

Structure Based Drug Design of Crizotinib (PF-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal–Epithelial Transition Factor (c-MET) Kinase and Anaplastic Lymphoma Kinase (ALK)

|Journal of Medicinal Chemistry|2011|924

Discovery of (10 <i>R</i> )-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro- <i>2H</i> -8,4-(metheno)pyrazolo[4,3- <i>h</i> ][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a Macrocyclic Inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1) with Preclinical Brain Exposure and Broad-Spectrum Potency against ALK-Resistant Mutations

|Journal of Medicinal Chemistry|2014|587

Using the Golden Triangle to optimize clearance and oral absorption

|Bioorganic & Medicinal Chemistry Letters|2009|382

Rapid assessment of a novel series of selective CB2 agonists using parallel synthesis protocols: A Lipophilic Efficiency (LipE) analysis

|Bioorganic & Medicinal Chemistry Letters|2009|269

Role of Physicochemical Properties and Ligand Lipophilicity Efficiency in Addressing Drug Safety Risks

|Annual reports in medicinal chemistry|2010|145