Discovery of (10 <i>R</i> )-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro- <i>2H</i> -8,4-(metheno)pyrazolo[4,3- <i>h</i> ][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a Macrocyclic Inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1) with Preclinical Brain Exposure and Broad-Spectrum Potency against ALK-Resistant Mutations
Ted W. Johnson(WorldFish), Martin P. Edwards(Pfizer (United States)), Paul Richardson(Pfizer (United States)), Alexei Brooun(Pfizer (United States)), Laura Lingardo(Pfizer (United States)), Huichun Zhu(Pfizer (United States)), Justine L. Lam(Pfizer (United States)), Helen Y. Zou(Centre for Cancer Biology), John C. Kath(Pfizer (United States)), Michele McTigue(Pfizer (United States)), Robert S. Kania(RG Biopharma (United States)), Michael R. Collins(Pfizer (United States)), Judith G. Deal(Pfizer (United States)), Sergei Timofeevski(Pfizer (United States)), Neal W. Sach(Pfizer (United States)), Simon Bailey(The University of Melbourne), J. Jean Cui(Southern Medical University), Qinhua Huang(Pfizer (United States)), Lars D. Engstrom(Mirati Therapeutics (United States)), Wei Liu(Second People’s Hospital of Yibin), Ya‐Li Deng(Pfizer (United States)), Mingying He(Pfizer (United States)), Robert L. Hoffman(Pfizer (United States)), Graham L. Smith(Pfizer (United States)), Cynthia L. Palmer(Pfizer (United States)), JinJiang Zhu(Pfizer (United States)), Phuong Le, Dac M. Dinh(Pfizer (United States)), Jacqui Hoffman(Pfizer (United States)), Albert Stewart(Pfizer (United States)), Tod Smeal(Pfizer (United States)), Hieu Lam(Pfizer (United States)), Benjamin J. Burke(Pfizer (United States))
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