A single-cell hematopoietic landscape resolves 8 lineage trajectories and defects in Kit mutant mice
Joakim S. Dahlin(Karolinska University Hospital), Fiona Hamey(Wellcome/MRC Cambridge Stem Cell Institute), Blanca Pijuan-Sala(Wellcome/MRC Cambridge Stem Cell Institute), Mairi Shepherd(Wellcome/MRC Cambridge Stem Cell Institute), Winnie Lau(Wellcome/MRC Cambridge Stem Cell Institute), Sonia Nestorowa(Wellcome/MRC Cambridge Stem Cell Institute), Caleb Weinreb(Harvard University), Samuel L. Wolock(Harvard University), Rebecca Hannah(Wellcome/MRC Cambridge Stem Cell Institute), Evangelia Diamanti(Wellcome/MRC Cambridge Stem Cell Institute), David G. Kent(Wellcome/MRC Cambridge Stem Cell Institute), Berthold Göttgens(Wellcome/MRC Cambridge Stem Cell Institute), Nicola K. Wilson(Wellcome/MRC Cambridge Stem Cell Institute)
Cited by 240Open Access
Abstract
expression. Potential compensatory processes included upregulation of the integrated stress response pathway and downregulation of proapoptotic gene expression in erythroid progenitors, thus providing a template of how large-scale single-cell transcriptomic studies can bridge between molecular phenotypes and quantitative population changes.
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