Prevalence of sexual dimorphism in mammalian phenotypic traits
Natasha A. Karp(AstraZeneca (United Kingdom)), Jeremy Mason(European Bioinformatics Institute), Arthur L. Beaudet(Baylor College of Medicine), Yoav Benjamini(Tel Aviv University), Lynette Bower(University of California, Davis), Robert E. Braun(Jackson Laboratory), Steve D. M. Brown(Mary Lyon Centre at MRC Harwell), Elissa J. Chesler(Jackson Laboratory), Mary E. Dickinson(Baylor College of Medicine), Ann M. Flenniken(Toronto Centre for Phenogenomics), Helmut Fuchs(Helmholtz Zentrum München), Martin Hrabě de Angelis(Helmholtz Zentrum München), Xiang Gao(Model Animal Research Center), Shiying Guo(Model Animal Research Center), Simon Greenaway(Mary Lyon Centre at MRC Harwell), Ruth Heller(Tel Aviv University), Yann Hérault(Centre National de la Recherche Scientifique), Monica J. Justice(Hospital for Sick Children), Natalja Kurbatova(Tel Aviv University), Christopher J. Lelliott(Wellcome Sanger Institute), K. C. Kent Lloyd(University of California, Davis), Ann‐Marie Mallon(Mary Lyon Centre at MRC Harwell), Judith E. Mank(University College London), Hiroshi Masuya(RIKEN BioResource Research Center), Colin McKerlie(Hospital for Sick Children), Terrence F. Meehan(European Bioinformatics Institute), Richard Mott(University College London), Stephen A. Murray(Jackson Laboratory), Helen Parkinson(European Bioinformatics Institute), Ramiro Ramírez‐Solis(Wellcome Sanger Institute), Luís Santos(Mary Lyon Centre at MRC Harwell), John R. Seavitt(Baylor College of Medicine), Damian Smedley(Queen Mary University of London), Tania Sorg(Centre National de la Recherche Scientifique), Anneliese O. Speak(Wellcome Sanger Institute), Karen P. Steel(King's College London), Karen L. Svenson(Jackson Laboratory), Yuichi Obata(RIKEN BioResource Research Center), Tomohiro Suzuki(RIKEN BioResource Research Center), Masaru Tamura(RIKEN BioResource Research Center), Hideki Kaneda(RIKEN BioResource Research Center), Tamio Furuse(RIKEN BioResource Research Center), Kimio Kobayashi(RIKEN BioResource Research Center), Ikuo Miura(RIKEN BioResource Research Center), Ikuko Yamada(RIKEN BioResource Research Center), Nobuhiko Tanaka(RIKEN BioResource Research Center), Atsushi Yoshiki(RIKEN BioResource Research Center), Shinya Ayabe(RIKEN BioResource Research Center), David Clary(University of California, Davis), Heather Tolentino(University of California, Davis), Michael Schuchbauer(University of California, Davis), Todd Tolentino(University of California, Davis), J Aprile(University of California, Davis), Sheryl Pedroia(University of California, Davis), Lois Kelsey(Toronto Centre for Phenogenomics), Igor Vukobradovic(Toronto Centre for Phenogenomics), Zorana Berberovic(Toronto Centre for Phenogenomics), Celeste Owen(Toronto Centre for Phenogenomics), Dawei Qu(Toronto Centre for Phenogenomics), Ruolin Guo(Toronto Centre for Phenogenomics), Susan Newbigging(Toronto Centre for Phenogenomics), Lily Morikawa(Toronto Centre for Phenogenomics), Napoleon Law(Toronto Centre for Phenogenomics), Xueyuan Shang(Toronto Centre for Phenogenomics), Patricia Feugas(Toronto Centre for Phenogenomics), Yanchun Wang(Toronto Centre for Phenogenomics), Mohammad Eskandarian(Toronto Centre for Phenogenomics), Yingchun Zhu(Toronto Centre for Phenogenomics), Lauryl M. J. Nutter(Toronto Centre for Phenogenomics), Patricia Penton(Toronto Centre for Phenogenomics), Valerie Laurin(Toronto Centre for Phenogenomics), Shannon Clarke(Toronto Centre for Phenogenomics), Qing Lan(Toronto Centre for Phenogenomics), Khondoker Sohel(Toronto Centre for Phenogenomics), D. Craig Miller(Toronto Centre for Phenogenomics), Greg Clark(Toronto Centre for Phenogenomics), Jane Hunter(Toronto Centre for Phenogenomics), Jorge Cabezas(Toronto Centre for Phenogenomics), Mohammed Bubshait(Toronto Centre for Phenogenomics), Tracy Carroll(Toronto Centre for Phenogenomics), Sandra Tondat(Toronto Centre for Phenogenomics), S. MacMaster(Toronto Centre for Phenogenomics), Monica Pereira(Toronto Centre for Phenogenomics), Marina Gertsenstein(Toronto Centre for Phenogenomics), Ozge Danisment(Toronto Centre for Phenogenomics), Elsa Jacob(Toronto Centre for Phenogenomics), Amie Creighton(Toronto Centre for Phenogenomics), Gillian Sleep(Toronto Centre for Phenogenomics), James D. Clark(Jackson Laboratory), Lydia Teboul(Mary Lyon Centre at MRC Harwell), Martin Fray(Mary Lyon Centre at MRC Harwell), Adam Caulder(Mary Lyon Centre at MRC Harwell), Jorik Loeffler(Mary Lyon Centre at MRC Harwell), Gemma Codner(Mary Lyon Centre at MRC Harwell), James Cleak(Mary Lyon Centre at MRC Harwell), Sara Johnson(Mary Lyon Centre at MRC Harwell), Zsombor Szoke-Kovacs(Mary Lyon Centre at MRC Harwell), Adam Radage(Mary Lyon Centre at MRC Harwell), Marina Maritati(Mary Lyon Centre at MRC Harwell), Joffrey Mianné(Mary Lyon Centre at MRC Harwell), Wendy Gardiner(Mary Lyon Centre at MRC Harwell), Susan Allen(Mary Lyon Centre at MRC Harwell), Heather Cater(Mary Lyon Centre at MRC Harwell), Michelle Stewart(Mary Lyon Centre at MRC Harwell), Piia Keskivali-Bond(Mary Lyon Centre at MRC Harwell), Caroline Sinclair(Wellcome Sanger Institute), Ellen Brown(Wellcome Sanger Institute), Brendan Doe(Wellcome Sanger Institute), Hannah Wardle‐Jones(Wellcome Sanger Institute), Evelyn Grau(Wellcome Sanger Institute), Nicola Griggs(Wellcome Sanger Institute), Mike Woods(Wellcome Sanger Institute), Helen Kundi(Wellcome Sanger Institute), Mark Griffiths(Wellcome Sanger Institute), Christian Kipp(Wellcome Sanger Institute), David Melvin(Wellcome Sanger Institute), Navis Pretheeba Raj(Wellcome Sanger Institute), S. Holroyd(Wellcome Sanger Institute), David J. Gannon(Wellcome Sanger Institute), Rafael Alcántara(Wellcome Sanger Institute), Antonella Galli(Wellcome Sanger Institute), Yvette Hooks(Wellcome Sanger Institute), Catherine Tudor(Wellcome Sanger Institute), Angela L. Green(Wellcome Sanger Institute), Fiona Kussy(Wellcome Sanger Institute), Elizabeth Tuck(Wellcome Sanger Institute), Emma Siragher(Wellcome Sanger Institute), Simon A. Maguire(Wellcome Sanger Institute), David Lafont(Wellcome Sanger Institute), Valerie E. Vancollie(Wellcome Sanger Institute), Selina Pearson(Wellcome Sanger Institute), Amy S. Gates(Wellcome Sanger Institute), Mark Sanderson(Wellcome Sanger Institute), Carl Shannon(Wellcome Sanger Institute), Lauren F. E. Anthony(Wellcome Sanger Institute), Maksymilian T. Sumowski(Wellcome Sanger Institute), Robbie S. B. McLaren(Wellcome Sanger Institute), Agnieszka Świątkowska(Wellcome Sanger Institute), Christopher Isherwood(Wellcome Sanger Institute), Emma L. Cambridge(Wellcome Sanger Institute), Heather Wilson(Wellcome Sanger Institute), Susana Caetano(Wellcome Sanger Institute), Cecilia Mazzeo(Wellcome Sanger Institute), Monika Dabrowska(Wellcome Sanger Institute), Charlotte Lillistone(Wellcome Sanger Institute), Jeanne Estabel(Wellcome Sanger Institute), Anna Karin B. Maguire(Wellcome Sanger Institute), Laura-Anne Roberson(Wellcome Sanger Institute), Guillaume Pavlovic(Institut Clinique de la Souris), Marie‐Christine Birling(Institut Clinique de la Souris), Wattenhofer-Donze Marie(Institut Clinique de la Souris), Sylvie Jacquot(Institut Clinique de la Souris), Abdel Ayadi(Institut Clinique de la Souris), Dalila Ali-Hadji(Institut Clinique de la Souris), Philippe Charles(Institut Clinique de la Souris), Philippe André(Institut Clinique de la Souris), Elise Le Marchand(Institut Clinique de la Souris), Amal El Amri(Institut Clinique de la Souris), Laurent Vasseur(Institut Clinique de la Souris), Juan Antonio Aguilar‐Pimentel(Helmholtz Zentrum München), Lore Becker(Helmholtz Zentrum München), Irina Treise(Helmholtz Zentrum München), Kristin Moreth(Helmholtz Zentrum München), Tobias Stoeger(Helmholtz Zentrum München), Oana V. Amarie(Helmholtz Zentrum München), Frauke Neff(Helmholtz Zentrum München), Wolfgang Wurst(German Center for Neurodegenerative Diseases), Raffi Bekeredjian(Heidelberg University), Markus Ollert(University of Southern Denmark), Thomas Klopstock(German Center for Neurodegenerative Diseases), Julia Calzada‐Wack(Helmholtz Zentrum München), Susan Marschall(Helmholtz Zentrum München), Robert Brommage(Helmholtz Zentrum München), Ralph Steinkamp(Helmholtz Zentrum München), Christoph Lengger(Helmholtz Zentrum München), Manuela A. Östereicher(Helmholtz Zentrum München), Holger Maier(Helmholtz Zentrum München), Claudia Stoeger(Helmholtz Zentrum München), Stefanie Leuchtenberger(Helmholtz Zentrum München), Ali Önder Yildrim(Helmholtz Zentrum München), Lillian Garrett(Helmholtz Zentrum München), Sabine M. Hölter(Helmholtz Zentrum München), Annemarie Zimprich(Helmholtz Zentrum München), Claudia Seisenberger(Helmholtz Zentrum München), Antje Bürger(Helmholtz Zentrum München), Jochen Graw(Helmholtz Zentrum München), Oliver Eickelberg(Helmholtz Zentrum München), Andreas Zimmer(University of Bonn), Eckhard Wolf(Ludwig-Maximilians-Universität München), Dirk H. Busch(Institute of Medical Microbiology and Hygiene), Martin Klingenspor(Fresenius (Germany)), Carsten B. Schmidt‐Weber(Helmholtz Zentrum München), Valérie Gailus‐Durner(Helmholtz Zentrum München), Johannes Beckers(Helmholtz Zentrum München), Birgit Rathkolb(Helmholtz Zentrum München), Jan Rozman(Helmholtz Zentrum München), Shigeharu Wakana(RIKEN BioResource Research Center), David West(Martin Luther King, Jr. Multi-Service Ambulatory Care Center), Sara Wells(Mary Lyon Centre at MRC Harwell), Henrik Westerberg(Mary Lyon Centre at MRC Harwell), Shay Yaacoby(Tel Aviv University), Jacqueline K. White(Wellcome Sanger Institute)
Cited by 271Open Access
Abstract
The role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 knockout lines), analysed for up to 234 traits, and found a large proportion of mammalian traits both in wildtype and mutants are influenced by sex. This result has implications for interpreting disease phenotypes in animal models and humans.
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