Cited by 1.3kOpen Access
Jackson Laboratory
ORCID: 0000-0002-0594-1702Publishes on CRISPR and Genetic Engineering, Congenital heart defects research, Pluripotent Stem Cells Research. 225 papers and 9.5k citations.
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The role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 knockout lines), analysed for up to 234 traits, and found a large proportion of mammalian traits both in wildtype and mutants are influenced by sex. This result has implications for interpreting disease phenotypes in animal models and humans.