Epigenetic clock analysis of diet, exercise, education, and lifestyle factors

Austin Quach(University of California, Los Angeles), Morgan E. Levine(University of California, Los Angeles), Toshiko Tanaka(National Institute on Aging), Ake T. Lu(University of California, Los Angeles), Brian H. Chen(National Institute on Aging), Luigi Ferrucci(National Institute on Aging), Beate Ritz(University of California, Los Angeles), Stefania Bandinelli(Azienda Sanitaria di Firenze), Marian L. Neuhouser(Fred Hutch Cancer Center), Jeannette M. Beasley(New York University), Linda Snetselaar(University of Iowa), Robert B. Wallace(University of Iowa), Philip S. Tsao(Stanford University), Devin Absher(HudsonAlpha Institute for Biotechnology), Themistocles L. Assimes(Stanford University), James D. Stewart(University of North Carolina at Chapel Hill), Yun Li(University of North Carolina at Chapel Hill), Lifang Hou(Northwestern University), Andrea Baccarelli(Columbia University), Eric A. Whitsel(University of North Carolina at Chapel Hill), Steve Horvath(University of California, Los Angeles)
Aging
February 14, 2017
10.18632/aging.101168
Cited by 876Open Access
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Abstract

)-an indicator of fruit and vegetable consumption, whereas intrinsic epigenetic age acceleration (IEAA) is associated with poultry intake (p=0.03) and BMI (p=0.05). Both EEAA and IEAA were also found to relate to indicators of metabolic syndrome, which appear to mediate their associations with BMI. Metformin-the first-line medication for the treatment of type 2 diabetes-does not delay epigenetic aging in this observational study. Finally, longitudinal data suggests that an increase in BMI is associated with increase in both EEAA and IEAA.Overall, the epigenetic age analysis of blood confirms the conventional wisdom regarding the benefits of eating a high plant diet with lean meats, moderate alcohol consumption, physical activity, and education, as well as the health risks of obesity and metabolic syndrome.

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