DNA methylation-based measures of biological age: meta-analysis predicting time to death
Brian H. Chen(National Institutes of Health), Riccardo E. Marioni(The University of Queensland), Elena Colicino(Columbia University), Marjolein J. Peters, Cavin Ward‐Caviness(Helmholtz Zentrum München), Pei-Chien Tsai(King's College London), Nicholas S. Roetker(University of Minnesota), Allan C. Just(Columbia University), Ellen W. Demerath(University of Minnesota), Weihua Guan(University of Minnesota), Jan Bressler(The University of Texas Health Science Center at Houston), Myriam Fornage(Baylor College of Medicine), Stephanie A. Studenski(National Institutes of Health), Amy R. Vandiver(Johns Hopkins University), Ann Zenobia Moore(National Institutes of Health), Toshiko Tanaka(National Institutes of Health), Douglas P. Kiel(Beth Israel Deaconess Medical Center), Liming Liang(Harvard University), Pantel Vokonas(Harvard University), Joel Schwartz(Harvard University), Kathryn L. Lunetta(Boston University), Joanne M. Murabito(Boston University), Stefania Bandinelli(Azienda Usl Toscana Centro), Dena Hernández(National Institutes of Health), David Melzer(University of Exeter), Michael A. Nalls(National Institutes of Health), Luke C. Pilling(University of Exeter), Timothy R. Price(National Institutes of Health), Andrew B. Singleton(National Institutes of Health), Christian Gieger(Helmholtz Zentrum München), Rolf Holle(Helmholtz Zentrum München), Anja Kretschmer(Helmholtz Zentrum München), Florian Kronenberg(Innsbruck Medical University), Sonja Kunze(Helmholtz Zentrum München), Jakob Linseisen(Helmholtz Zentrum München), Christine Meisinger(Helmholtz Zentrum München), Wolfgang Rathmann(Deutsches Diabetes-Zentrum e.V.), Mélanie Waldenberger(Helmholtz Zentrum München), Peter M. Visscher(The University of Queensland), Sonia Shah(The University of Queensland), Naomi R. Wray(The University of Queensland), Allan F. McRae(The University of Queensland), Oscar H. Franco(Erasmus University Rotterdam), Albert Hofman(Harvard University), André G. Uitterlinden(Erasmus University Rotterdam), Devin Absher(HudsonAlpha Institute for Biotechnology), Themistocles L. Assimes(University of California, Los Angeles), Morgan E. Levine(VA Palo Alto Health Care System), Ake T. Lu(VA Palo Alto Health Care System), Philip S. Tsao(Northwestern University), Lifang Hou(Northwestern University), JoAnn E. Manson(Children's National), Cara L. Carty(University of California San Diego), Andrea Z. LaCroix(University of Washington), Alex P. Reiner(Johns Hopkins University), Tim D. Spector(King's College London), Andrew P. Feinberg(National Institutes of Health), Daniel Levy(Harvard University), Andrea Baccarelli(Columbia University), Joyce B. J. van Meurs, Jordana T. Bell(King's College London), Annette Peters(Helmholtz Zentrum München), Ian J. Deary(University of California, Los Angeles), James S. Pankow(University of Minnesota), Luigi Ferrucci(National Institutes of Health), Steve Horvath(University of California, Los Angeles)
Cited by 1,209Open Access
Abstract
). Overall, this study a) strengthens the evidence that epigenetic age predicts all-cause mortality above and beyond chronological age and traditional risk factors, and b) demonstrates that epigenetic age estimates that incorporate information on blood cell counts lead to highly significant associations with all-cause mortality.
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