Identification of genetic determinants of breast cancer immune phenotypes by integrative genome-scale analysis
Wouter Hendrickx(Sidra Medical and Research Center), Ines Simeone(University of Sannio), Samreen Anjum(Hamad bin Khalifa University), Younes Mokrab(Eli Lilly (United Kingdom)), François Bertucci(Centre National de la Recherche Scientifique), Pascal Finetti(Centre National de la Recherche Scientifique), Giuseppe Curigliano(European Institute of Oncology), Barbara Seliger(Martin Luther University Halle-Wittenberg), Luigi Cerulo(University of Sannio), Sara Tomei(Sidra Medical and Research Center), Lucia Gemma Delogu(University of Sassari), Cristina Maccalli(Sidra Medical and Research Center), Ena Wang(Sidra Medical and Research Center), Lance D. Miller(Wake Forest University), Francesco M. Marincola(Sidra Medical and Research Center), Michele Ceccarelli(University of Sannio), Davide Bedognetti(Sidra Medical and Research Center)
Cited by 189Open Access
Abstract
mutations were tightly associated with an immune-unfavorable phenotype (ICR1). Using both the TCGA and the validation dataset, the degree of MAPK deregulation segregates breast tumors according to their immune disposition. These findings suggest that mutation-driven perturbations of MAPK pathways are linked to the negative regulation of intratumoral immune response in breast cancer. Modulations of MAPK pathways could be experimentally tested to enhance breast cancer immune sensitivity.
Related Papers
No related papers found
Powered by citation graph analysis