Cited by 8.1kOpen Access
Sidra Medical and Research Center
ORCID: 0000-0003-1611-6692Publishes on Genetic Associations and Epidemiology, Genomics and Rare Diseases, Genomic variations and chromosomal abnormalities. 85 papers and 21.9k citations.
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mutations were tightly associated with an immune-unfavorable phenotype (ICR1). Using both the TCGA and the validation dataset, the degree of MAPK deregulation segregates breast tumors according to their immune disposition. These findings suggest that mutation-driven perturbations of MAPK pathways are linked to the negative regulation of intratumoral immune response in breast cancer. Modulations of MAPK pathways could be experimentally tested to enhance breast cancer immune sensitivity.