CD74 is a novel transcription regulator

Naama Gil-Yarom(Weizmann Institute of Science), Lihi Radomir(Weizmann Institute of Science), Lital Sever(Weizmann Institute of Science), Matthias P. Kramer(Weizmann Institute of Science), Hadas Lewinsky(Weizmann Institute of Science), Chamutal Bornstein(Weizmann Institute of Science), Ronnie Blecher‐Gonen(Weizmann Institute of Science), Zohar Barnett‐Itzhaki(Weizmann Institute of Science), Vita Mirkin(Kaplan Medical Center), Gilgi Friedlander(Weizmann Institute of Science), Lev Shvidel(Kaplan Medical Center), Yair Herishanu(Tel Aviv University), Elias Lolis(Yale University), Shirly Becker-Herman(Weizmann Institute of Science), Ido Amit(Weizmann Institute of Science), Idit Shachar(Weizmann Institute of Science)
Proceedings of the National Academy of Sciences
December 28, 2016
10.1073/pnas.1612195114
Cited by 153Open Access
Full Text

Abstract

CD74 is a cell-surface receptor for the cytokine macrophage migration inhibitory factor. Macrophage migration inhibitory factor binding to CD74 induces its intramembrane cleavage and the release of its cytosolic intracellular domain (CD74-ICD), which regulates cell survival. In the present study, we characterized the transcriptional activity of CD74-ICD in chronic lymphocytic B cells. We show that following CD74 activation, CD74-ICD interacts with the transcription factors RUNX (Runt related transcription factor) and NF-κB and binds to proximal and distal regulatory sites enriched for genes involved in apoptosis, immune response, and cell migration. This process leads to regulation of expression of these genes. Our results suggest that identifying targets of CD74 will help in understanding of essential pathways regulating B-cell survival in health and disease.

Related Papers

No related papers found

Powered by citation graph analysis