Long-term maintenance of human naïve T cells through in situ homeostasis in lymphoid tissue sites

Joseph J.C. Thome(Columbia University Irving Medical Center), Boris Grinshpun(Columbia University Irving Medical Center), Brahma V. Kumar(Columbia University Irving Medical Center), Masaru Kubota(Columbia University Irving Medical Center), Yoshiaki Ohmura(Columbia University Irving Medical Center), Harvey Lerner, Gregory D. Sempowski(Duke University), Yufeng Shen(Columbia University Irving Medical Center), Donna L. Färber(Columbia University Irving Medical Center)
Science Immunology
December 15, 2016
10.1126/sciimmunol.aah6506
Cited by 158Open Access
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Abstract

Human naïve T cells are maintained in lymph nodes for decades and clonally expand in situ after cessation of thymopoiesis.

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