Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade
Kristen E. Pauken(University of Pennsylvania), Morgan A. Sammons(University of Pennsylvania), Pamela M. Odorizzi(University of Pennsylvania), Sasikanth Manne(University of Pennsylvania), Jernej Godec(Harvard University), Omar Khan(University of Pennsylvania), Adam Drake(University of Pennsylvania), Zeyu Chen(University of Pennsylvania), Debattama R. Sen(Dana-Farber Cancer Institute), Makoto Kurachi(University of Pennsylvania), R. Anthony Barnitz(Dana-Farber Cancer Institute), Caroline Bartman(University of Pennsylvania), Bertram Bengsch(University of Pennsylvania), Alexander C. Huang(University of Pennsylvania), Jason M. Schenkel(University of Minnesota), Golnaz Vahedi(University of Pennsylvania), W. Nicholas Haining(Broad Institute), Shelley L. Berger(University of Pennsylvania), E. John Wherry(University of Pennsylvania)
Cited by 1,281
Abstract
epigenetic landscape. These data indicate that epigenetic fate inflexibility may limit current immunotherapies.