Cited by 8.5k
University of California San Diego Medical Center
ORCID: 0000-0003-4735-5514Publishes on Gene expression and cancer classification, Genetics, Bioinformatics, and Biomedical Research, Cancer Genomics and Diagnostics. 112 papers and 30.9k citations.
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To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this "Connectivity Map" resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project.